Pegvisomant Improves Insulin Sensitivity and Reduces Overnight Free Fatty Acid Concentrations in Patients with Acromegaly

Introduction: Acromegaly is complicated by an increased incidence of diabetes mellitus caused by impaired insulin sensitivity and reduced β-cell function. Pegvisomant blocks activity at GH receptors, normalizing IGF-I in over 90% of patients and improving insulin sensitivity. The mechanisms for this...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2009-07, Vol.94 (7), p.2459-2463
Hauptverfasser:	Higham, C. E., Rowles, S., Russell-Jones, D., Umpleby, A. M., Trainer, P. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly - blood Acromegaly - drug therapy Acromegaly - metabolism Adult Biological and medical sciences Circadian Rhythm - drug effects Endocrinopathies Fatty Acids, Nonesterified - blood Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glucose - metabolism Hormone Antagonists - pharmacology Hormone Antagonists - therapeutic use Human Growth Hormone - analogs & derivatives Human Growth Hormone - pharmacology Human Growth Hormone - therapeutic use Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Insulin Resistance Insulin-Like Growth Factor I - analysis Lipid Metabolism - drug effects Longitudinal Studies Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Osmolar Concentration Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
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