High‐resolution analysis of 16q22.1 in breast carcinoma using DNA amplifiable probes (multiplex amplifiable probe hybridization technique) and immunohistochemistry

Loss of the chromosomal material at 16q22.1 is one of the most frequent genetic aberrations found in both lobular and low‐grade nonlobular invasive carcinoma of the breast, indicating the presence of a tumour suppressor gene (TSG) at this region in these tumours. However, the TSG (s) at the 16q22.1...

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Veröffentlicht in:	International journal of cancer 2005-05, Vol.114 (5), p.720-729
Hauptverfasser:	Rakha, Emad A., Armour, John A.L., Pinder, Sarah E., Paish, Claire E., Ellis, Ian O.
Format:	Artikel
Sprache:	eng
Schlagworte:	16q22.1 Antigens, CD Biological and medical sciences breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cadherins - metabolism candidate genes Carcinoma - genetics CCCTC-Binding Factor Chromosome Aberrations Chromosomes, Human, Pair 16 DNA - genetics DNA Primers - chemistry DNA-Binding Proteins - metabolism E2F4 Transcription Factor Genital system. Mammary gland Humans Immunohistochemistry - methods Investigative techniques, diagnostic techniques (general aspects) MAPH, immunohistochemistry Medical sciences Oligonucleotide Array Sequence Analysis - methods Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase Chain Reaction Repressor Proteins - metabolism Telomeric Repeat Binding Protein 2 - metabolism Transcription Factors - metabolism Tumors
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