Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study

Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increase...

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Veröffentlicht in:	Neurology 2005-02, Vol.64 (4), p.728-730
Hauptverfasser:	VANITALLIE, T. B, NONAS, C, DI ROCCO, A, BOYAR, K, HYAMS, K, HEYMSFIELD, S. B
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid - metabolism Acetoacetates - metabolism Aged Antiparkinson Agents - therapeutic use Biological and medical sciences Cholesterol - blood Combined Modality Therapy Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dietary Carbohydrates - administration & dosage Dietary Carbohydrates - adverse effects Dietary Carbohydrates - therapeutic use Dietary Fats - administration & dosage Dietary Fats - adverse effects Dietary Fats - classification Dietary Fats - therapeutic use Dietary Proteins - administration & dosage Electron Transport Complex I - metabolism Energy Metabolism Feasibility Studies Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Hypercholesterolemia - etiology Hypercholesterolemia - prevention & control Ketones - blood Male Medical sciences Middle Aged Mitochondria - metabolism Nervous system (semeiology, syndromes) Neurology Neurons - metabolism Outpatients Oxidative Stress Parkinson Disease - diet therapy Parkinson Disease - drug therapy Parkinson Disease - metabolism Patient Compliance Treatment Outcome Weight Loss
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