Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study
Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increase...
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| Veröffentlicht in: | Neurology 2005-02, Vol.64 (4), p.728-730 |
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| container_title | Neurology |
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| creator | VANITALLIE, T. B NONAS, C DI ROCCO, A BOYAR, K HYAMS, K HEYMSFIELD, S. B |
| description | Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out. |
| doi_str_mv | 10.1212/01.WNL.0000152046.11390.45 |
| format | Article |
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Prion diseases ; Dietary Carbohydrates - administration & dosage ; Dietary Carbohydrates - adverse effects ; Dietary Carbohydrates - therapeutic use ; Dietary Fats - administration & dosage ; Dietary Fats - adverse effects ; Dietary Fats - classification ; Dietary Fats - therapeutic use ; Dietary Proteins - administration & dosage ; Electron Transport Complex I - metabolism ; Energy Metabolism ; Feasibility Studies ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Hypercholesterolemia - etiology ; Hypercholesterolemia - prevention & control ; Ketones - blood ; Male ; Medical sciences ; Middle Aged ; Mitochondria - metabolism ; Nervous system (semeiology, syndromes) ; Neurology ; Neurons - metabolism ; Outpatients ; Oxidative Stress ; Parkinson Disease - diet therapy ; Parkinson Disease - drug therapy ; Parkinson Disease - metabolism ; Patient Compliance ; Treatment Outcome ; Weight Loss</subject><ispartof>Neurology, 2005-02, Vol.64 (4), p.728-730</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-8b1f3d4aca52cc460b717ebabfae4ab36b5ef99986237a7008e6cf102b2a300c3</citedby><cites>FETCH-LOGICAL-c404t-8b1f3d4aca52cc460b717ebabfae4ab36b5ef99986237a7008e6cf102b2a300c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16531469$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15728303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VANITALLIE, T. B</creatorcontrib><creatorcontrib>NONAS, C</creatorcontrib><creatorcontrib>DI ROCCO, A</creatorcontrib><creatorcontrib>BOYAR, K</creatorcontrib><creatorcontrib>HYAMS, K</creatorcontrib><creatorcontrib>HEYMSFIELD, S. B</creatorcontrib><title>Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study</title><title>Neurology</title><addtitle>Neurology</addtitle><description>Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. 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Prion diseases</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Carbohydrates - adverse effects</subject><subject>Dietary Carbohydrates - therapeutic use</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - adverse effects</subject><subject>Dietary Fats - classification</subject><subject>Dietary Fats - therapeutic use</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Electron Transport Complex I - metabolism</subject><subject>Energy Metabolism</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Hypercholesterolemia - etiology</subject><subject>Hypercholesterolemia - prevention & control</subject><subject>Ketones - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitochondria - metabolism</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Outpatients</subject><subject>Oxidative Stress</subject><subject>Parkinson Disease - diet therapy</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - metabolism</subject><subject>Patient Compliance</subject><subject>Treatment Outcome</subject><subject>Weight Loss</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LHEEQhhsx6Gr8C2EQzG0m1Z8z400kmsCS5LASb013TzV2nI-1u4ew_95RF7YuRRXPWwUPIZcUKsoo-wa0-vtrXcFSVDIQqqKUt1AJeURWy0aVirPHY7ICYE3Jm7o5JWcp_XvH6_aEnFJZs4YDX5HNJqLJA465mHzxx8TnMKZpLLqQ0CQs_of8tAyYyzB2s8OueNptMT5jnkYcgrkubgq_kMGGPuRdkfLc7T6TT970CS_2_Zw83H3f3P4o17_vf97erEsnQOSysdTzThhnJHNOKLA1rdEa6w0KY7myEn3bto1ivDY1QIPKeQrMMsMBHD8nXz_ubuP0MmPKegjJYd-bEac5aVUL2bZSLeD1B-jilFJEr7cxDCbuNAX95lQD1YtTfXCq351qIZfwl_2X2Q7YHaJ7iQtwtQdMcqb30YwupAOnJKdCtfwVf9WBBw</recordid><startdate>20050222</startdate><enddate>20050222</enddate><creator>VANITALLIE, T. B</creator><creator>NONAS, C</creator><creator>DI ROCCO, A</creator><creator>BOYAR, K</creator><creator>HYAMS, K</creator><creator>HEYMSFIELD, S. B</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050222</creationdate><title>Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study</title><author>VANITALLIE, T. B ; NONAS, C ; DI ROCCO, A ; BOYAR, K ; HYAMS, K ; HEYMSFIELD, S. B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-8b1f3d4aca52cc460b717ebabfae4ab36b5ef99986237a7008e6cf102b2a300c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>3-Hydroxybutyric Acid - metabolism</topic><topic>Acetoacetates - metabolism</topic><topic>Aged</topic><topic>Antiparkinson Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - blood</topic><topic>Combined Modality Therapy</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Carbohydrates - adverse effects</topic><topic>Dietary Carbohydrates - therapeutic use</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - adverse effects</topic><topic>Dietary Fats - classification</topic><topic>Dietary Fats - therapeutic use</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Electron Transport Complex I - metabolism</topic><topic>Energy Metabolism</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Hypercholesterolemia - etiology</topic><topic>Hypercholesterolemia - prevention & control</topic><topic>Ketones - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitochondria - metabolism</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neurons - metabolism</topic><topic>Outpatients</topic><topic>Oxidative Stress</topic><topic>Parkinson Disease - diet therapy</topic><topic>Parkinson Disease - drug therapy</topic><topic>Parkinson Disease - metabolism</topic><topic>Patient Compliance</topic><topic>Treatment Outcome</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VANITALLIE, T. B</creatorcontrib><creatorcontrib>NONAS, C</creatorcontrib><creatorcontrib>DI ROCCO, A</creatorcontrib><creatorcontrib>BOYAR, K</creatorcontrib><creatorcontrib>HYAMS, K</creatorcontrib><creatorcontrib>HEYMSFIELD, S. B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VANITALLIE, T. B</au><au>NONAS, C</au><au>DI ROCCO, A</au><au>BOYAR, K</au><au>HYAMS, K</au><au>HEYMSFIELD, S. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2005-02-22</date><risdate>2005</risdate><volume>64</volume><issue>4</issue><spage>728</spage><epage>730</epage><pages>728-730</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15728303</pmid><doi>10.1212/01.WNL.0000152046.11390.45</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neurology, 2005-02, Vol.64 (4), p.728-730 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | 3-Hydroxybutyric Acid - metabolism Acetoacetates - metabolism Aged Antiparkinson Agents - therapeutic use Biological and medical sciences Cholesterol - blood Combined Modality Therapy Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dietary Carbohydrates - administration & dosage Dietary Carbohydrates - adverse effects Dietary Carbohydrates - therapeutic use Dietary Fats - administration & dosage Dietary Fats - adverse effects Dietary Fats - classification Dietary Fats - therapeutic use Dietary Proteins - administration & dosage Electron Transport Complex I - metabolism Energy Metabolism Feasibility Studies Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Hypercholesterolemia - etiology Hypercholesterolemia - prevention & control Ketones - blood Male Medical sciences Middle Aged Mitochondria - metabolism Nervous system (semeiology, syndromes) Neurology Neurons - metabolism Outpatients Oxidative Stress Parkinson Disease - diet therapy Parkinson Disease - drug therapy Parkinson Disease - metabolism Patient Compliance Treatment Outcome Weight Loss |
| title | Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study |
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