Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

Integration of genome-wide expression profiling with linkage analysis is a new approach to identifying genes underlying complex traits. We applied this approach to the regulation of gene expression in the BXH/HXB panel of rat recombinant inbred strains, one of the largest available rodent recombinan...

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Veröffentlicht in:	Nature genetics 2005-03, Vol.37 (3), p.243-253
Hauptverfasser:	Hubner, Norbert, Wallace, Caroline A, Zimdahl, Heike, Petretto, Enrico, Schulz, Herbert, Maciver, Fiona, Mueller, Michael, Hummel, Oliver, Monti, Jan, Zidek, Vaclav, Musilova, Alena, Kren, Vladimir, Causton, Helen, Game, Laurence, Born, Gabriele, Schmidt, Sabine, Müller, Anita, Cook, Stuart A, Kurtz, Theodore W, Whittaker, John, Pravenec, Michal, Aitman, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood Pressure - genetics Cancer Research Cardiovascular diseases Classical genetics, quantitative genetics, hybrids Datasets Disease Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Function Gene mapping Genes Genetic Linkage Genetic resources Genetic transcription Genetics Genetics of eukaryotes. Biological and molecular evolution Genomes Genomics Human Genetics Human populations Hypertension Identification and classification Linkage (Genetics) Metabolic disorders Metabolic syndrome Methods, theories and miscellaneous Molecular and cellular biology Molecular genetics Physiological aspects Physiology Quantitative Trait Loci Rats Recombination, Genetic Rodents Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing
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