Autocrine IL-10 Induces Hallmarks of Alternative Activation in Macrophages and Suppresses Antituberculosis Effector Mechanisms without Compromising T Cell Immunity

Elevated IL-10 has been implicated in reactivation tuberculosis (TB). Since macrophages rather than T cells were reported to be the major source of IL-10 in TB, we analyzed the consequences of a macrophage-specific overexpression of IL-10 in transgenic mice (macIL-10-transgenic) after aerosol infect...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-07, Vol.183 (2), p.1301-1312
Hauptverfasser:	Schreiber, Tanja, Ehlers, Stefan, Heitmann, Lisa, Rausch, Alexandra, Mages, Jorg, Murray, Peter J, Lang, Roland, Holscher, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginase - genetics Autocrine Communication - immunology Gene Expression Profiling Interleukin-10 - physiology Lung - metabolism Lung - microbiology Macrophage Activation - immunology Macrophages - metabolism Mice Mice, Transgenic Mycobacterium tuberculosis T-Lymphocytes - immunology Tuberculosis - immunology
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