Tumor Cells Deactivate Human Monocytes by Up-Regulating IL-1 Receptor Associated Kinase-M Expression via CD44 and TLR4

Although blood monocytes possess significant cytotoxic activity against tumor cells, tumor-infiltrating monocytes are commonly deactivated in cancer patients. Monocytes pre-exposed to tumor cells show significantly decreased expression levels of TNF-alpha, IL-12p40, and IL-1R-associated kinase (IRAK...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2005-03, Vol.174 (5), p.3032-3040
Hauptverfasser:	del Fresno, Carlos, Otero, Karel, Gomez-Garcia, Lourdes, Gonzalez-Leon, Maria Carmen, Soler-Ranger, Llanos, Fuentes-Prior, Pablo, Escoll, Pedro, Baos, Rosa, Caveda, Luis, Garcia, Felipe, Arnalich, Francisco, Lopez-Collazo, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Blocking - pharmacology Cell Communication - immunology Cell Line, Tumor Coculture Techniques Down-Regulation - immunology Gene Expression Regulation, Neoplastic - immunology HeLa Cells HL-60 Cells Humans Hyaluronan Receptors - immunology Hyaluronan Receptors - physiology Hyaluronic Acid - pharmacology Interleukin-1 Receptor-Associated Kinases Jurkat Cells Macrophage Activation - immunology Male Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - immunology Membrane Glycoproteins - physiology Middle Aged Monocytes - immunology Monocytes - metabolism Protein Kinases - biosynthesis Protein Kinases - genetics Protein Kinases - metabolism Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - immunology Receptors, Cell Surface - physiology Receptors, Interleukin-1 - biosynthesis RNA, Messenger - antagonists & inhibitors RNA, Messenger - biosynthesis Toll-Like Receptor 4 Toll-Like Receptors Tumor Cells, Cultured Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Up-Regulation - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!