Divergent Oncogenic Changes Influence Survival Differences between Colon and Rectal Adenocarcinomas

PURPOSE:Colorectal cancers develop through various mechanisms such as chromosomal instability, DNA mismatch repair deficiency (microsatellite instability), and epigenetic DNA promoter methylation (CpG island methylator phenotype). This study evaluated the disparity in neoplastic changes between colo...

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Veröffentlicht in:	Diseases of the colon & rectum 2009-06, Vol.52 (6), p.1039-1045
Hauptverfasser:	Kalady, Matthew F, Sanchez, Julian A, Manilich, Elena, Hammel, Jeff, Casey, Graham, Church, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Adult Biological and medical sciences Chi-Square Distribution Colonic Neoplasms - genetics Colonic Neoplasms - pathology CpG Islands DNA Methylation DNA Mutational Analysis Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Microsatellite Instability Middle Aged Neoplasm Staging Phenotype Proportional Hazards Models Proto-Oncogene Proteins B-raf - genetics ras Proteins - genetics Rectal Neoplasms - genetics Rectal Neoplasms - pathology Statistics, Nonparametric Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors
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