The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha RI binding and serum killing of bacteria

The staphylococcal superantigen-like proteins (SSLs) are close relatives of the superantigens but are coded for by a separate gene cluster within a 19-kb region of the pathogenicity island SaPIn2. rSSL7 (formally known as SET1) bound with high affinity (K(D), 1.1 nM) to the monomeric form of human I...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-03, Vol.174 (5), p.2926-2933
Hauptverfasser:	Langley, Ries, Wines, Bruce, Willoughby, Natasha, Basu, Indira, Proft, Thomas, Fraser, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, CD - metabolism Bacterial Proteins - metabolism Bacterial Proteins - pharmacology Binding, Competitive - immunology Cattle Colostrum - immunology Colostrum - metabolism Complement C5 - metabolism Escherichia coli Exotoxins - metabolism Exotoxins - pharmacology Hemolysis - immunology Humans Immunoglobulin A - blood Immunoglobulin A - metabolism Immunoglobulin A, Secretory - metabolism Mice Milk, Human - immunology Milk, Human - metabolism Molecular Sequence Data Pan troglodytes Papio Protein Binding - immunology Rabbits Rats Receptors, Fc - antagonists & inhibitors Receptors, Fc - metabolism Saliva - immunology Saliva - metabolism Serum Bactericidal Test Sheep Staphylococcus aureus Staphylococcus aureus - growth & development Staphylococcus aureus - immunology Superantigens - metabolism Superantigens - pharmacology Swine Tears - immunology Tears - metabolism
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