Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, podocin, and CD2 associated protein in cultured human podocytes

Podocytes are critical in maintaining the filtration barrier of the glomerulus and are dependent on the slit diaphragm (SD) proteins nephrin, podocin, and CD2-associated protein (CD2AP) to function optimally. The effects of normal human plasma and nephrotic plasma on podocytes were tested, focusing...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2005-03, Vol.16 (3), p.629-637
Hauptverfasser:	COWARD, Richard J. M, FOSTER, Rebecca R, PATTON, David, LAN NI, LENNON, Rachel, BATES, David O, HARPER, Steven J, MATHIESON, Peter W, SALEEM, Moin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adaptor Proteins, Signal Transducing Adolescent Biological and medical sciences Blood Proteins - pharmacology Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Cell Line, Transformed Child Cytoskeletal Proteins Female Glomerulonephritis Humans Infant Intracellular Signaling Peptides and Proteins Kidney Glomerulus - cytology Kidney Glomerulus - metabolism Male Medical sciences Membrane Proteins - metabolism Middle Aged Mutation Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nephrosis - blood Proteins - genetics Proteins - metabolism
Online-Zugang:	Volltext
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