Mucosal immunosenescence: new developments and vaccines to control infectious diseases
Infection of the aero-digestive tract represents a major disease burden of the elderly, and despite recent advances in our understanding of the mucosal immune system, its immunosenescence remains poorly defined. Age-associated alterations of the intestinal and respiratory immune systems occur at dis...
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| Veröffentlicht in: | Trends in immunology 2009-07, Vol.30 (7), p.334-343 |
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| creator | Fujihashi, Kohtaro Kiyono, Hiroshi |
| description | Infection of the aero-digestive tract represents a major disease burden of the elderly, and despite recent advances in our understanding of the mucosal immune system, its immunosenescence remains poorly defined. Age-associated alterations of the intestinal and respiratory immune systems occur at distinct times and in a distinct manner. A reduction in gut-associated lymphoreticular tissues, intestinal antigen-specific IgA antibody responses and lack of oral tolerance induction are all associated with aging. By contrast, nasopharyngeal-associated lymphoreticular tissue function remains intact during aging with notable signs of immunosenescence seen only in the elderly. The distinct timing of mucosal immunosenescence seen between the gut and respiratory system suggests the nasal route of vaccination might be preferable for effective mucosal vaccines in the elderly. |
| doi_str_mv | 10.1016/j.it.2009.04.004 |
| format | Article |
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Age-associated alterations of the intestinal and respiratory immune systems occur at distinct times and in a distinct manner. A reduction in gut-associated lymphoreticular tissues, intestinal antigen-specific IgA antibody responses and lack of oral tolerance induction are all associated with aging. By contrast, nasopharyngeal-associated lymphoreticular tissue function remains intact during aging with notable signs of immunosenescence seen only in the elderly. 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Age-associated alterations of the intestinal and respiratory immune systems occur at distinct times and in a distinct manner. A reduction in gut-associated lymphoreticular tissues, intestinal antigen-specific IgA antibody responses and lack of oral tolerance induction are all associated with aging. By contrast, nasopharyngeal-associated lymphoreticular tissue function remains intact during aging with notable signs of immunosenescence seen only in the elderly. The distinct timing of mucosal immunosenescence seen between the gut and respiratory system suggests the nasal route of vaccination might be preferable for effective mucosal vaccines in the elderly.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - immunology</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Bacteria</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Cellular Senescence - immunology</subject><subject>Communicable Disease Control</subject><subject>Communicable Diseases - immunology</subject><subject>Communicable Diseases - microbiology</subject><subject>Cytokines</subject><subject>Dendritic Cells - immunology</subject><subject>Grants</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immune Tolerance</subject><subject>Immunity, Mucosal</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin A - metabolism</subject><subject>Intestinal Mucosa - immunology</subject><subject>Lymphocytes</subject><subject>Mucous membrane</subject><subject>Nasal Mucosa - immunology</subject><subject>Rodents</subject><subject>Streptococcus infections</subject><subject>Vaccines - immunology</subject><issn>1471-4906</issn><issn>1471-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1rFTEUxYMotlb3rmRA6O6NN5OPmXQhSKlVaOnCj23IZG4gz5nkmcw86X9vhvdooQtdJYTfOeSecwl5S6GmQOWHbe3nugFQNfAagD8jp5S3dMNVR58_3EGekFc5bwGoaNv2JTmhSnDoKD0lP28XG7MZKz9NS4gZA2aLweJFFfBPNeAex7ibMMy5MmGo9sZaX5hqjpWNYU6xSINDO_u45GrwGU3G_Jq8cGbM-OZ4npEfn6--X37Z3Nxdf738dLOxXDbzhinVDo7THqA3HQg2yMZ0wjTCWTvQzojeUVR9K_vGOWYtNk6htILx8tAJdkbOD767FH8vmGc9-fL_cTQBy3-0bLmQTNH_giVEWcJZHd8_AbdxSaEMoakAqXjDoSkUHCibYs4Jnd4lP5l0rynotRq91X5eXZUGrks1RfLuaLz0Ew6PgmMXBbg4AFgC23tMOlu_VjH4VPLVQ_T_cv_4RGxHH7w14y-8x_w4g86NBv1tXY11M0CVrQDG2F9LY7N0</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Fujihashi, Kohtaro</creator><creator>Kiyono, Hiroshi</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Mucosal immunosenescence: new developments and vaccines to control infectious diseases</title><author>Fujihashi, Kohtaro ; 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| ispartof | Trends in immunology, 2009-07, Vol.30 (7), p.334-343 |
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| subjects | Age Aged Aged, 80 and over Aging Aging - immunology Allergy and Immunology Animals Bacteria CD4-Positive T-Lymphocytes - immunology Cellular Senescence - immunology Communicable Disease Control Communicable Diseases - immunology Communicable Diseases - microbiology Cytokines Dendritic Cells - immunology Grants Humans Immune system Immune Tolerance Immunity, Mucosal Immunoglobulin A - immunology Immunoglobulin A - metabolism Intestinal Mucosa - immunology Lymphocytes Mucous membrane Nasal Mucosa - immunology Rodents Streptococcus infections Vaccines - immunology |
| title | Mucosal immunosenescence: new developments and vaccines to control infectious diseases |
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