Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis
Tenascin‐C (TN‐C) is an extracellular matrix protein that is expressed transiently in close association with tissue remodelling in various body sites. In the heart, TN‐C is only present during early stages of development, is not expressed in the normal adult, but reappears in pathological states. Th...
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| Veröffentlicht in: | The Journal of pathology 2005-03, Vol.205 (4), p.460-467 |
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| creator | Morimoto, Shin-ichiro Imanaka-Yoshida, Kyoko Hiramitsu, Shinya Kato, Shigeru Ohtsuki, Masatsugu Uemura, Akihisa Kato, Yasuchika Nishikawa, Toshio Toyozaki, Tetsuya Hishida, Hitoshi Yoshida, Toshimichi Hiroe, Michiaki |
| description | Tenascin‐C (TN‐C) is an extracellular matrix protein that is expressed transiently in close association with tissue remodelling in various body sites. In the heart, TN‐C is only present during early stages of development, is not expressed in the normal adult, but reappears in pathological states. The purpose of this study was to analyse the expression of TN‐C in myocardial tissue from myocarditis patients, and to evaluate the diagnostic value of immunostaining for TN‐C in the assessment of inflammatory activity in biopsy specimens. A total of 113 biopsy specimens obtained from 32 patients with a clinical diagnosis of acute myocarditis were examined by immunohistochemistry and in situ hybridization for TN‐C. The immunostaining was semi‐quantified and compared with histological diagnosis according to the Dallas criteria. Furthermore, serial biopsies from 22 patients were taken during convalescence, and sequential changes in TN‐C levels were analysed. Expression of TN‐C was specifically detected in endomyocardial biopsy specimens from patients with active‐stage inflammation, and disappeared in healed stages. The degree of expression of TN‐C correlated with the severity of histological lesions. These data suggest that TN‐C reflects disease activity in cases of human myocarditis. Immunostaining for TN‐C could enhance the sensitivity and accuracy of diagnosis using biopsy specimens. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/path.1730 |
| format | Article |
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In the heart, TN‐C is only present during early stages of development, is not expressed in the normal adult, but reappears in pathological states. The purpose of this study was to analyse the expression of TN‐C in myocardial tissue from myocarditis patients, and to evaluate the diagnostic value of immunostaining for TN‐C in the assessment of inflammatory activity in biopsy specimens. A total of 113 biopsy specimens obtained from 32 patients with a clinical diagnosis of acute myocarditis were examined by immunohistochemistry and in situ hybridization for TN‐C. The immunostaining was semi‐quantified and compared with histological diagnosis according to the Dallas criteria. Furthermore, serial biopsies from 22 patients were taken during convalescence, and sequential changes in TN‐C levels were analysed. Expression of TN‐C was specifically detected in endomyocardial biopsy specimens from patients with active‐stage inflammation, and disappeared in healed stages. The degree of expression of TN‐C correlated with the severity of histological lesions. These data suggest that TN‐C reflects disease activity in cases of human myocarditis. Immunostaining for TN‐C could enhance the sensitivity and accuracy of diagnosis using biopsy specimens. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1730</identifier><identifier>PMID: 15685595</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Acute Disease ; Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biomarkers - analysis ; Biopsy ; Cardiology. Vascular system ; Child ; diagnosis ; extracellular matrix ; Female ; Heart ; human ; Humans ; Immunohistochemistry - methods ; immunostaining ; In Situ Hybridization ; inflammation ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; myocarditis ; Myocarditis - metabolism ; Myocarditis. Cardiomyopathies ; Myocardium - metabolism ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; tenascin ; Tenascin - analysis</subject><ispartof>The Journal of pathology, 2005-03, Vol.205 (4), p.460-467</ispartof><rights>Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4570-d79dc4c0ec3ca5365f3a5b6ce866192a9a0ef3ee67b92abbf97fc7d2f23a8fda3</citedby><cites>FETCH-LOGICAL-c4570-d79dc4c0ec3ca5365f3a5b6ce866192a9a0ef3ee67b92abbf97fc7d2f23a8fda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1730$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1730$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16575531$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15685595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morimoto, Shin-ichiro</creatorcontrib><creatorcontrib>Imanaka-Yoshida, Kyoko</creatorcontrib><creatorcontrib>Hiramitsu, Shinya</creatorcontrib><creatorcontrib>Kato, Shigeru</creatorcontrib><creatorcontrib>Ohtsuki, Masatsugu</creatorcontrib><creatorcontrib>Uemura, Akihisa</creatorcontrib><creatorcontrib>Kato, Yasuchika</creatorcontrib><creatorcontrib>Nishikawa, Toshio</creatorcontrib><creatorcontrib>Toyozaki, Tetsuya</creatorcontrib><creatorcontrib>Hishida, Hitoshi</creatorcontrib><creatorcontrib>Yoshida, Toshimichi</creatorcontrib><creatorcontrib>Hiroe, Michiaki</creatorcontrib><title>Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>Tenascin‐C (TN‐C) is an extracellular matrix protein that is expressed transiently in close association with tissue remodelling in various body sites. In the heart, TN‐C is only present during early stages of development, is not expressed in the normal adult, but reappears in pathological states. The purpose of this study was to analyse the expression of TN‐C in myocardial tissue from myocarditis patients, and to evaluate the diagnostic value of immunostaining for TN‐C in the assessment of inflammatory activity in biopsy specimens. A total of 113 biopsy specimens obtained from 32 patients with a clinical diagnosis of acute myocarditis were examined by immunohistochemistry and in situ hybridization for TN‐C. The immunostaining was semi‐quantified and compared with histological diagnosis according to the Dallas criteria. Furthermore, serial biopsies from 22 patients were taken during convalescence, and sequential changes in TN‐C levels were analysed. Expression of TN‐C was specifically detected in endomyocardial biopsy specimens from patients with active‐stage inflammation, and disappeared in healed stages. The degree of expression of TN‐C correlated with the severity of histological lesions. These data suggest that TN‐C reflects disease activity in cases of human myocarditis. Immunostaining for TN‐C could enhance the sensitivity and accuracy of diagnosis using biopsy specimens. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Biopsy</subject><subject>Cardiology. Vascular system</subject><subject>Child</subject><subject>diagnosis</subject><subject>extracellular matrix</subject><subject>Female</subject><subject>Heart</subject><subject>human</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>immunostaining</subject><subject>In Situ Hybridization</subject><subject>inflammation</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocarditis</subject><subject>Myocarditis - metabolism</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Myocardium - metabolism</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>tenascin</subject><subject>Tenascin - analysis</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1v1DAQBmALgehSOPAHUC4gcUhrx7G9PpYtbKmqwqGoEhdr4oxZQz4W22m7_x4vG9ETJ8ueZ2bkl5DXjJ4wSqvTLaTNCVOcPiELRrUs9VLLp2SRa1XJa6aOyIsYf1JKtRbiOTliQi6F0GJBvp97-DGMMXlbTMl3Pu2K0RUJB4jWD-WqcGMo8A66CZIfh7_FDRZgk7-b8WbqYcgvU8Ki340WQuuTjy_JMwddxFfzeUy-ffp4s7oor76sP6_OrkpbC0XLVunW1pai5RYEl8JxEI20uJSS6Qo0UHQcUaom35rGaeWsaitXcVi6FvgxeXeYuw3j7wljMr2PFrsOBhynaKSqhajrOsP3B2jDGGNAZ7bB9xB2hlGzD9LsgzT7ILN9Mw-dmh7bRzknl8HbGeSgoHMBBuvjo5NCCcFZdqcHd-873P1_o_l6dnMxry4PHT4mfPjXAeFX_gpXwtxer81qfXn54fx2ba75Hxpbm7E</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Morimoto, Shin-ichiro</creator><creator>Imanaka-Yoshida, Kyoko</creator><creator>Hiramitsu, Shinya</creator><creator>Kato, Shigeru</creator><creator>Ohtsuki, Masatsugu</creator><creator>Uemura, Akihisa</creator><creator>Kato, Yasuchika</creator><creator>Nishikawa, Toshio</creator><creator>Toyozaki, Tetsuya</creator><creator>Hishida, Hitoshi</creator><creator>Yoshida, Toshimichi</creator><creator>Hiroe, Michiaki</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200503</creationdate><title>Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis</title><author>Morimoto, Shin-ichiro ; Imanaka-Yoshida, Kyoko ; Hiramitsu, Shinya ; Kato, Shigeru ; Ohtsuki, Masatsugu ; Uemura, Akihisa ; Kato, Yasuchika ; Nishikawa, Toshio ; Toyozaki, Tetsuya ; Hishida, Hitoshi ; Yoshida, Toshimichi ; Hiroe, Michiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4570-d79dc4c0ec3ca5365f3a5b6ce866192a9a0ef3ee67b92abbf97fc7d2f23a8fda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Biopsy</topic><topic>Cardiology. Vascular system</topic><topic>Child</topic><topic>diagnosis</topic><topic>extracellular matrix</topic><topic>Female</topic><topic>Heart</topic><topic>human</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>immunostaining</topic><topic>In Situ Hybridization</topic><topic>inflammation</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocarditis</topic><topic>Myocarditis - metabolism</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Myocardium - metabolism</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>tenascin</topic><topic>Tenascin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morimoto, Shin-ichiro</creatorcontrib><creatorcontrib>Imanaka-Yoshida, Kyoko</creatorcontrib><creatorcontrib>Hiramitsu, Shinya</creatorcontrib><creatorcontrib>Kato, Shigeru</creatorcontrib><creatorcontrib>Ohtsuki, Masatsugu</creatorcontrib><creatorcontrib>Uemura, Akihisa</creatorcontrib><creatorcontrib>Kato, Yasuchika</creatorcontrib><creatorcontrib>Nishikawa, Toshio</creatorcontrib><creatorcontrib>Toyozaki, Tetsuya</creatorcontrib><creatorcontrib>Hishida, Hitoshi</creatorcontrib><creatorcontrib>Yoshida, Toshimichi</creatorcontrib><creatorcontrib>Hiroe, Michiaki</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morimoto, Shin-ichiro</au><au>Imanaka-Yoshida, Kyoko</au><au>Hiramitsu, Shinya</au><au>Kato, Shigeru</au><au>Ohtsuki, Masatsugu</au><au>Uemura, Akihisa</au><au>Kato, Yasuchika</au><au>Nishikawa, Toshio</au><au>Toyozaki, Tetsuya</au><au>Hishida, Hitoshi</au><au>Yoshida, Toshimichi</au><au>Hiroe, Michiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>2005-03</date><risdate>2005</risdate><volume>205</volume><issue>4</issue><spage>460</spage><epage>467</epage><pages>460-467</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>Tenascin‐C (TN‐C) is an extracellular matrix protein that is expressed transiently in close association with tissue remodelling in various body sites. In the heart, TN‐C is only present during early stages of development, is not expressed in the normal adult, but reappears in pathological states. The purpose of this study was to analyse the expression of TN‐C in myocardial tissue from myocarditis patients, and to evaluate the diagnostic value of immunostaining for TN‐C in the assessment of inflammatory activity in biopsy specimens. A total of 113 biopsy specimens obtained from 32 patients with a clinical diagnosis of acute myocarditis were examined by immunohistochemistry and in situ hybridization for TN‐C. The immunostaining was semi‐quantified and compared with histological diagnosis according to the Dallas criteria. Furthermore, serial biopsies from 22 patients were taken during convalescence, and sequential changes in TN‐C levels were analysed. Expression of TN‐C was specifically detected in endomyocardial biopsy specimens from patients with active‐stage inflammation, and disappeared in healed stages. The degree of expression of TN‐C correlated with the severity of histological lesions. These data suggest that TN‐C reflects disease activity in cases of human myocarditis. Immunostaining for TN‐C could enhance the sensitivity and accuracy of diagnosis using biopsy specimens. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>15685595</pmid><doi>10.1002/path.1730</doi><tpages>8</tpages></addata></record> |
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| subjects | Acute Disease Adolescent Adult Aged Biological and medical sciences Biomarkers - analysis Biopsy Cardiology. Vascular system Child diagnosis extracellular matrix Female Heart human Humans Immunohistochemistry - methods immunostaining In Situ Hybridization inflammation Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged myocarditis Myocarditis - metabolism Myocarditis. Cardiomyopathies Myocardium - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques tenascin Tenascin - analysis |
| title | Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis |
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