Hot-spot mutations in hepatitis B virus core gene: eliciting or evading immune clearance?

The biological implications of substitutions L60V and I97L in the core (c) gene of hepatitis B virus (HBV) were investigated in order to determine whether they could change the immunogenicity of HBcAg or influence the immune response in mice. Three strains of recombinant adenoviruses – AdHBV‐WT, AdH...

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Veröffentlicht in:	Journal of viral hepatitis 2005-03, Vol.12 (2), p.146-153
Hauptverfasser:	Liu, Z., Luo, K., He, H., Hou, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - genetics Antibody Formation - immunology Base Sequence Cells, Cultured Disease Models, Animal DNA, Viral - analysis Female Hepatitis B - genetics Hepatitis B - immunology Hepatitis B Core Antigens - genetics Hepatitis B Core Antigens - immunology Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology immune response Immunity, Cellular - genetics Immunity, Cellular - immunology Male Mice Mice, Inbred BALB C Molecular Sequence Data Mutation Probability recombinant adenovirus Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity Viral Core Proteins - genetics Viral Core Proteins - immunology
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