The epidermal growth factor receptor as a target for colorectal cancer therapy

The epidermal growth factor receptor (EGFR) is the prototypical member of the erbB receptor family. The EGFR axis is activated by a variety of ligands that are crucial in the formation and propagation of many tumors, including colorectal cancer, through their effects on cell signaling pathways, cell...

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Veröffentlicht in:	Seminars in oncology 2005-02, Vol.32 (1), p.52-60
Hauptverfasser:	Lockhart, Craig, Berlin, Jordan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines Aniline Compounds Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cell Transformation, Neoplastic Cetuximab Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Disease Progression Erlotinib Hydrochloride Humans Organic Chemicals - therapeutic use Prognosis Pyrimidines - therapeutic use Pyrroles - therapeutic use Quinazolines - therapeutic use Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - physiology Signal Transduction
Online-Zugang:	Volltext
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