Bone Marrow Is a Major Reservoir and Site of Recruitment for Central Memory CD8 + T Cells

Normal bone marrow (BM) contains T cells whose function and origin are poorly understood. We observed that CD8 + T cells in BM consist chiefly of CCR7 + L-selectin + central memory cells (T CMs). Adoptively transferred T CMs accumulated more efficiently in the BM than naive and effector T cells. Int...

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