Stem cells and solid cancers
Recently, there have been significant advances in our knowledge of stem cells found in tissues that can develop solid tumours. In particular, novel stem cell markers have been identified for the first time identifying multipotential cells: a required characteristic of a stem cell. The scarcity of ca...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2009-07, Vol.455 (1), p.1-13 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | McDonald, Stuart A. C. Graham, Trevor A. Schier, Stefanie Wright, Nicholas A. Alison, Malcolm R. |
| description | Recently, there have been significant advances in our knowledge of stem cells found in tissues that can develop solid tumours. In particular, novel stem cell markers have been identified for the first time identifying multipotential cells: a required characteristic of a stem cell. The scarcity of cancer stem cells has been questioned. Current dogma states that they are rare, but novel research has suggested that this may not be the case. Here, we review the latest literature on stem cells, particularly cancer stem cells within solid tumours. We discuss current thinking on how stem cells develop into cancer stem cells and how they protect themselves from doing so and do they express unique markers that can be used to detect stem cells. We attempt to put into perspective these latest advances in stem cell biology and their potential for cancer therapy. |
| doi_str_mv | 10.1007/s00428-009-0783-1 |
| format | Article |
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We discuss current thinking on how stem cells develop into cancer stem cells and how they protect themselves from doing so and do they express unique markers that can be used to detect stem cells. 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| identifier | ISSN: 0945-6317 |
| ispartof | Virchows Archiv : an international journal of pathology, 2009-07, Vol.455 (1), p.1-13 |
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| language | eng |
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| subjects | AC133 Antigen Adult Stem Cells - physiology Animals Antigens, CD - analysis Biological and medical sciences Biomarkers Cell Division Glycoproteins - analysis Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Medicine Medicine & Public Health Neoplasms - etiology Neoplasms - pathology Neoplastic Stem Cells - pathology Neoplastic Stem Cells - physiology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peptides - analysis Review and Perspective Stem cells Stem Cells - physiology |
| title | Stem cells and solid cancers |
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