Down syndrome screening in the United States in 2001 and 2007: a survey of maternal-fetal medicine specialists
Objective The purpose of this study was to determine changes in screening and performance of invasive diagnostic procedures for Down syndrome between 2001 and 2007. Study Design The Society for Maternal-Fetal Medicine members completed a survey in 2007 regarding screening tests and diagnostic proced...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2009-07, Vol.201 (1), p.97.e1-97.e5 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Fang, Yu Ming Victor, MD Benn, Peter, DSc Campbell, Winston, MD Bolnick, Jay, MD Prabulos, Anne Marie, MD Egan, James F.X., MD |
| description | Objective The purpose of this study was to determine changes in screening and performance of invasive diagnostic procedures for Down syndrome between 2001 and 2007. Study Design The Society for Maternal-Fetal Medicine members completed a survey in 2007 regarding screening tests and diagnostic procedures for Down syndrome. With the use of descriptive statistics, the χ2 test, and the Student t test, responses from 2007 were compared with responses from a similar 2001 survey. Results Performance of first-trimester screening more than doubled from 2001-2007 (43.1% in 2001, 97.3% in 2007; P < .0001). Between 2001 and 2007, the use of the quad screen increased 10-fold (8.5% in 2001, 85.6% in 2007; P < .0001). There was an estimated 20% decrease in invasive diagnostic procedures that were performed in risk-positive women (53.7% in 2001, 34.2% in 2007; P < .0001). In 2007, the average fetal loss rates that were quoted by maternal-fetal medicine specialists after chorionic villous sampling was 1:160 and after an amniocentesis was 1:493. Conclusion Down syndrome screening evolved from 2001-2007, with an increasing emphasis on first-trimester screening. With more efficacious screening, the number of invasive procedures has declined. |
| doi_str_mv | 10.1016/j.ajog.2009.02.029 |
| format | Article |
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Study Design The Society for Maternal-Fetal Medicine members completed a survey in 2007 regarding screening tests and diagnostic procedures for Down syndrome. With the use of descriptive statistics, the χ2 test, and the Student t test, responses from 2007 were compared with responses from a similar 2001 survey. Results Performance of first-trimester screening more than doubled from 2001-2007 (43.1% in 2001, 97.3% in 2007; P < .0001). Between 2001 and 2007, the use of the quad screen increased 10-fold (8.5% in 2001, 85.6% in 2007; P < .0001). There was an estimated 20% decrease in invasive diagnostic procedures that were performed in risk-positive women (53.7% in 2001, 34.2% in 2007; P < .0001). In 2007, the average fetal loss rates that were quoted by maternal-fetal medicine specialists after chorionic villous sampling was 1:160 and after an amniocentesis was 1:493. Conclusion Down syndrome screening evolved from 2001-2007, with an increasing emphasis on first-trimester screening. With more efficacious screening, the number of invasive procedures has declined.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2009.02.029</identifier><identifier>PMID: 19467637</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; amniocentesis ; Amniocentesis - trends ; Biological and medical sciences ; Certification - statistics & numerical data ; Chorionic Villi Sampling - trends ; chorionic villous sampling ; Chromosome aberrations ; Down syndrome ; Down Syndrome - diagnosis ; Down Syndrome - diagnostic imaging ; Female ; first-trimester screening ; Gynecology. Andrology. Obstetrics ; Health Care Surveys ; Humans ; Medical genetics ; Medical sciences ; Obstetrics - standards ; Obstetrics and Gynecology ; Practice Patterns, Physicians' - statistics & numerical data ; Practice Patterns, Physicians' - trends ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Prenatal Diagnosis - trends ; quad screen ; Ultrasonography, Prenatal ; United States</subject><ispartof>American journal of obstetrics and gynecology, 2009-07, Vol.201 (1), p.97.e1-97.e5</ispartof><rights>Mosby, Inc.</rights><rights>2009 Mosby, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-f9a3ffa4f5b6ea0a09626cc787351abb1a3a77e46c5b6d798172cdd8941713003</citedby><cites>FETCH-LOGICAL-c439t-f9a3ffa4f5b6ea0a09626cc787351abb1a3a77e46c5b6d798172cdd8941713003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937809002208$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21684079$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19467637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Yu Ming Victor, MD</creatorcontrib><creatorcontrib>Benn, Peter, DSc</creatorcontrib><creatorcontrib>Campbell, Winston, MD</creatorcontrib><creatorcontrib>Bolnick, Jay, MD</creatorcontrib><creatorcontrib>Prabulos, Anne Marie, MD</creatorcontrib><creatorcontrib>Egan, James F.X., MD</creatorcontrib><title>Down syndrome screening in the United States in 2001 and 2007: a survey of maternal-fetal medicine specialists</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The purpose of this study was to determine changes in screening and performance of invasive diagnostic procedures for Down syndrome between 2001 and 2007. Study Design The Society for Maternal-Fetal Medicine members completed a survey in 2007 regarding screening tests and diagnostic procedures for Down syndrome. With the use of descriptive statistics, the χ2 test, and the Student t test, responses from 2007 were compared with responses from a similar 2001 survey. Results Performance of first-trimester screening more than doubled from 2001-2007 (43.1% in 2001, 97.3% in 2007; P < .0001). Between 2001 and 2007, the use of the quad screen increased 10-fold (8.5% in 2001, 85.6% in 2007; P < .0001). There was an estimated 20% decrease in invasive diagnostic procedures that were performed in risk-positive women (53.7% in 2001, 34.2% in 2007; P < .0001). In 2007, the average fetal loss rates that were quoted by maternal-fetal medicine specialists after chorionic villous sampling was 1:160 and after an amniocentesis was 1:493. Conclusion Down syndrome screening evolved from 2001-2007, with an increasing emphasis on first-trimester screening. With more efficacious screening, the number of invasive procedures has declined.</description><subject>Adult</subject><subject>amniocentesis</subject><subject>Amniocentesis - trends</subject><subject>Biological and medical sciences</subject><subject>Certification - statistics & numerical data</subject><subject>Chorionic Villi Sampling - trends</subject><subject>chorionic villous sampling</subject><subject>Chromosome aberrations</subject><subject>Down syndrome</subject><subject>Down Syndrome - diagnosis</subject><subject>Down Syndrome - diagnostic imaging</subject><subject>Female</subject><subject>first-trimester screening</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health Care Surveys</subject><subject>Humans</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Obstetrics - standards</subject><subject>Obstetrics and Gynecology</subject><subject>Practice Patterns, Physicians' - statistics & numerical data</subject><subject>Practice Patterns, Physicians' - trends</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy Trimester, Second</subject><subject>Prenatal Diagnosis - trends</subject><subject>quad screen</subject><subject>Ultrasonography, Prenatal</subject><subject>United States</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkuLFDEUhQtRnJ7RP-BCstFdtXlUJxWRAZnxBQMuxlmH26lbY8rqVJtbNdL_3oRuFFwIgTz4zrnJya2qF4KvBRf6zbCGYbpfS87tmss87KNqJbg1tW51-7hacc5lbZVpz6pzoqFspZVPqzNhG220MqsqXk-_IqND7NK0Q0Y-IcYQ71mIbP6O7C6GGTt2O8OMVA5zNcEgdmVh3jJgtKQHPLCpZ7vMpAhj3eMMI9thF3yI2XSPPsAYaKZn1ZMeRsLnp_miuvv44dvV5_rm66cvV-9vat8oO9e9BdX30PSbrUbgwK2W2nvTGrURsN0KUGAMNtpnoDO2FUb6rmttI4xQnKuL6vXRd5-mnwvS7HaBPI4jRJwWcto0GyFUm0F5BH2aiBL2bp_CDtLBCe5Kym5wJWVXUnZc5mGz6OXJfdnmV_6VnGLNwKsTAORh7BNEH-gPJ4VuG26K0bsjhzmLh4DJkQ8YfU4uoZ9dN4X_3-PyH7kfQwy54g88IA3TUr6DnHCUBe62NEBpB25LJ_BW_QaRJq63</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Fang, Yu Ming Victor, MD</creator><creator>Benn, Peter, DSc</creator><creator>Campbell, Winston, MD</creator><creator>Bolnick, Jay, MD</creator><creator>Prabulos, Anne Marie, MD</creator><creator>Egan, James F.X., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Down syndrome screening in the United States in 2001 and 2007: a survey of maternal-fetal medicine specialists</title><author>Fang, Yu Ming Victor, MD ; Benn, Peter, DSc ; Campbell, Winston, MD ; Bolnick, Jay, MD ; Prabulos, Anne Marie, MD ; Egan, James F.X., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-f9a3ffa4f5b6ea0a09626cc787351abb1a3a77e46c5b6d798172cdd8941713003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>amniocentesis</topic><topic>Amniocentesis - trends</topic><topic>Biological and medical sciences</topic><topic>Certification - statistics & numerical data</topic><topic>Chorionic Villi Sampling - trends</topic><topic>chorionic villous sampling</topic><topic>Chromosome aberrations</topic><topic>Down syndrome</topic><topic>Down Syndrome - diagnosis</topic><topic>Down Syndrome - diagnostic imaging</topic><topic>Female</topic><topic>first-trimester screening</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health Care Surveys</topic><topic>Humans</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Obstetrics - standards</topic><topic>Obstetrics and Gynecology</topic><topic>Practice Patterns, Physicians' - statistics & numerical data</topic><topic>Practice Patterns, Physicians' - trends</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy Trimester, Second</topic><topic>Prenatal Diagnosis - trends</topic><topic>quad screen</topic><topic>Ultrasonography, Prenatal</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Yu Ming Victor, MD</creatorcontrib><creatorcontrib>Benn, Peter, DSc</creatorcontrib><creatorcontrib>Campbell, Winston, MD</creatorcontrib><creatorcontrib>Bolnick, Jay, MD</creatorcontrib><creatorcontrib>Prabulos, Anne Marie, MD</creatorcontrib><creatorcontrib>Egan, James F.X., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Yu Ming Victor, MD</au><au>Benn, Peter, DSc</au><au>Campbell, Winston, MD</au><au>Bolnick, Jay, MD</au><au>Prabulos, Anne Marie, MD</au><au>Egan, James F.X., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Down syndrome screening in the United States in 2001 and 2007: a survey of maternal-fetal medicine specialists</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>201</volume><issue>1</issue><spage>97.e1</spage><epage>97.e5</epage><pages>97.e1-97.e5</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective The purpose of this study was to determine changes in screening and performance of invasive diagnostic procedures for Down syndrome between 2001 and 2007. Study Design The Society for Maternal-Fetal Medicine members completed a survey in 2007 regarding screening tests and diagnostic procedures for Down syndrome. With the use of descriptive statistics, the χ2 test, and the Student t test, responses from 2007 were compared with responses from a similar 2001 survey. Results Performance of first-trimester screening more than doubled from 2001-2007 (43.1% in 2001, 97.3% in 2007; P < .0001). Between 2001 and 2007, the use of the quad screen increased 10-fold (8.5% in 2001, 85.6% in 2007; P < .0001). There was an estimated 20% decrease in invasive diagnostic procedures that were performed in risk-positive women (53.7% in 2001, 34.2% in 2007; P < .0001). In 2007, the average fetal loss rates that were quoted by maternal-fetal medicine specialists after chorionic villous sampling was 1:160 and after an amniocentesis was 1:493. Conclusion Down syndrome screening evolved from 2001-2007, with an increasing emphasis on first-trimester screening. With more efficacious screening, the number of invasive procedures has declined.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19467637</pmid><doi>10.1016/j.ajog.2009.02.029</doi><tpages>3</tpages></addata></record> |
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| issn | 0002-9378 1097-6868 |
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| subjects | Adult amniocentesis Amniocentesis - trends Biological and medical sciences Certification - statistics & numerical data Chorionic Villi Sampling - trends chorionic villous sampling Chromosome aberrations Down syndrome Down Syndrome - diagnosis Down Syndrome - diagnostic imaging Female first-trimester screening Gynecology. Andrology. Obstetrics Health Care Surveys Humans Medical genetics Medical sciences Obstetrics - standards Obstetrics and Gynecology Practice Patterns, Physicians' - statistics & numerical data Practice Patterns, Physicians' - trends Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Prenatal Diagnosis - trends quad screen Ultrasonography, Prenatal United States |
| title | Down syndrome screening in the United States in 2001 and 2007: a survey of maternal-fetal medicine specialists |
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