3D Hyperpolarized (129)Xe MRI of mouse lung at low xenon concentration using a continuous flow-type hyperpolarizing system: feasibility for quantitative measurement of regional ventilation

We investigated the feasibility of 3D hyperpolarized (HP) (129)Xe magnetic resonance (MR) imaging at an extremely low concentration of HP (129)Xe supplied from a continuous flow-type hyperpolarizing (CF-HP) system and established a standard procedure for measuring regional lung ventilation of small...

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Veröffentlicht in:	Magnetic resonance in medical sciences 2009, Vol.8 (2), p.73-79
Hauptverfasser:	Hori, Yuki, Kimura, Atsuomi, Wakayama, Tetsuya, Kitamoto, Masakazu, Imai, Fumito, Imai, Hirohiko, Fujiwara, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Equipment Design Feasibility Studies Imaging, Three-Dimensional Lung - anatomy & histology Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Male Mice Mice, Inbred Strains Xenon Isotopes
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Zusammenfassung:	We investigated the feasibility of 3D hyperpolarized (HP) (129)Xe magnetic resonance (MR) imaging at an extremely low concentration of HP (129)Xe supplied from a continuous flow-type hyperpolarizing (CF-HP) system and established a standard procedure for measuring regional lung ventilation of small animals, such as the mouse, as a baseline for further studies. We performed 3D HP (129)Xe MR imaging of the lungs of 2 healthy and 2 emphysematous mice that were spontaneously breathing diluted HP (129)Xe (
ISSN:	1347-3182
DOI:	10.2463/mrms.8.73