Functional and structural alterations induced by copper in xanthine oxidase

Xanthine oxidase (XO), a key enzyme in purine metabolism, produces reactive oxygen species causing vascular injuries and chronic heart failure. Here, copper's ability to alter XO activity and structure was investigated in vitro after pre-incubation of the enzyme with increasing Cu2+ concentrati...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2009-07, Vol.41 (7), p.603-617
Hauptverfasser:	Hadizadeh, Mahnaz, Keyhani, Ezzatollah, Keyhani, Jacqueline, Khodadadi, Cyrus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocatalysis - drug effects Cattle Circular Dichroism Copper - chemistry Copper - metabolism Copper - pharmacology Kinetics Models, Molecular Protein Binding Protein Structure, Secondary Protein Structure, Tertiary Spectrometry, Fluorescence Xanthine Oxidase - chemistry Xanthine Oxidase - metabolism
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