Mortality analysis of patients undergoing lung transplantation for emphysema

Mortality analysis of patients undergoing lung transplantation for emphysema

BACKGROUNDThe outcomes of lung transplantation 11 years after starting the transplantation program in our hospital are presented. Risk factors associated with short-, medium-, and long-term mortality in transplant recipients were analyzed.PATIENTS AND METHODSAll patients diagnosed with emphysema who...

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Veröffentlicht in:Archivos de bronconeumología (English ed.) 2009-07, Vol.45 (7), p.335-340
Hauptverfasser: Miñambres, Eduardo, Zurbano, Felipe, Naranjo, Sara, Llorca, Javier, Cifrián, José Manuel, González-Castro, Alejandro
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container_issue 7
container_start_page 335
container_title Archivos de bronconeumología (English ed.)
container_volume 45
creator Miñambres, Eduardo
Zurbano, Felipe
Naranjo, Sara
Llorca, Javier
Cifrián, José Manuel
González-Castro, Alejandro
description BACKGROUNDThe outcomes of lung transplantation 11 years after starting the transplantation program in our hospital are presented. Risk factors associated with short-, medium-, and long-term mortality in transplant recipients were analyzed.PATIENTS AND METHODSAll patients diagnosed with emphysema who underwent lung transplantation between March 1997 and June 2008 were included. The association between different study variables and early death and death at 1 year and 5 years was studied. The Kaplan-Meier method was used to analyze survival. A logistic regression model was used to study the association between early death and variables with a trend towards significance (P
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Risk factors associated with short-, medium-, and long-term mortality in transplant recipients were analyzed.PATIENTS AND METHODSAll patients diagnosed with emphysema who underwent lung transplantation between March 1997 and June 2008 were included. The association between different study variables and early death and death at 1 year and 5 years was studied. The Kaplan-Meier method was used to analyze survival. A logistic regression model was used to study the association between early death and variables with a trend towards significance (P&lt;.2) in the univariate analysis. The risk factors for mortality at 1 year and 5 years were analyzed by a Cox regression model.RESULTSA total of 92 patients were included. Survival was 89.3%, 70%, and 54% at 1 month, 1 year, and 5 years after transplantation, respectively. Dehiscence of the surgical suture (P&lt;.001), duration of mechanical ventilation in the intensive care unit (P=.04), duration of the surgical procedure (P&lt;.001), and single-lung transplantation (P=.007) were the variables associated with mortality. Extracorporeal circulation and the need for hemodiafiltration in the intensive care unit increased the short-term risk of death (P&lt;.05). The age of the recipient was the variable associated with long-term mortality (P=.02). The duration of the surgical intervention was associated with an increase in short-, medium-, and long-term mortality.CONCLUSIONSComplications were responsible for short-term mortality, while age of the recipient was the most important factor in determining long-term survival. Mortality was higher in single-lung transplant recipients compared to double-lung transplant recipients.</description><identifier>EISSN: 1579-2129</identifier><identifier>DOI: 10.1016/j.arbres.2009.01.011</identifier><language>spa</language><ispartof>Archivos de bronconeumología (English ed.), 2009-07, Vol.45 (7), p.335-340</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Miñambres, Eduardo</creatorcontrib><creatorcontrib>Zurbano, Felipe</creatorcontrib><creatorcontrib>Naranjo, Sara</creatorcontrib><creatorcontrib>Llorca, Javier</creatorcontrib><creatorcontrib>Cifrián, José Manuel</creatorcontrib><creatorcontrib>González-Castro, Alejandro</creatorcontrib><title>Mortality analysis of patients undergoing lung transplantation for emphysema</title><title>Archivos de bronconeumología (English ed.)</title><description>BACKGROUNDThe outcomes of lung transplantation 11 years after starting the transplantation program in our hospital are presented. Risk factors associated with short-, medium-, and long-term mortality in transplant recipients were analyzed.PATIENTS AND METHODSAll patients diagnosed with emphysema who underwent lung transplantation between March 1997 and June 2008 were included. The association between different study variables and early death and death at 1 year and 5 years was studied. The Kaplan-Meier method was used to analyze survival. A logistic regression model was used to study the association between early death and variables with a trend towards significance (P&lt;.2) in the univariate analysis. The risk factors for mortality at 1 year and 5 years were analyzed by a Cox regression model.RESULTSA total of 92 patients were included. Survival was 89.3%, 70%, and 54% at 1 month, 1 year, and 5 years after transplantation, respectively. Dehiscence of the surgical suture (P&lt;.001), duration of mechanical ventilation in the intensive care unit (P=.04), duration of the surgical procedure (P&lt;.001), and single-lung transplantation (P=.007) were the variables associated with mortality. Extracorporeal circulation and the need for hemodiafiltration in the intensive care unit increased the short-term risk of death (P&lt;.05). The age of the recipient was the variable associated with long-term mortality (P=.02). The duration of the surgical intervention was associated with an increase in short-, medium-, and long-term mortality.CONCLUSIONSComplications were responsible for short-term mortality, while age of the recipient was the most important factor in determining long-term survival. 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Risk factors associated with short-, medium-, and long-term mortality in transplant recipients were analyzed.PATIENTS AND METHODSAll patients diagnosed with emphysema who underwent lung transplantation between March 1997 and June 2008 were included. The association between different study variables and early death and death at 1 year and 5 years was studied. The Kaplan-Meier method was used to analyze survival. A logistic regression model was used to study the association between early death and variables with a trend towards significance (P&lt;.2) in the univariate analysis. The risk factors for mortality at 1 year and 5 years were analyzed by a Cox regression model.RESULTSA total of 92 patients were included. Survival was 89.3%, 70%, and 54% at 1 month, 1 year, and 5 years after transplantation, respectively. Dehiscence of the surgical suture (P&lt;.001), duration of mechanical ventilation in the intensive care unit (P=.04), duration of the surgical procedure (P&lt;.001), and single-lung transplantation (P=.007) were the variables associated with mortality. Extracorporeal circulation and the need for hemodiafiltration in the intensive care unit increased the short-term risk of death (P&lt;.05). The age of the recipient was the variable associated with long-term mortality (P=.02). The duration of the surgical intervention was associated with an increase in short-, medium-, and long-term mortality.CONCLUSIONSComplications were responsible for short-term mortality, while age of the recipient was the most important factor in determining long-term survival. Mortality was higher in single-lung transplant recipients compared to double-lung transplant recipients.</abstract><doi>10.1016/j.arbres.2009.01.011</doi><tpages>6</tpages></addata></record>
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title Mortality analysis of patients undergoing lung transplantation for emphysema
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