Iridium-Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols

Iridium-Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols

Nothing to sm(Ir)k at: Under appropriate reaction conditions, iridium hydride catalysts promote the isomerization of primary allylic alcohols. The best catalysts, like (R)-1 (P green, O red, N blue, Ir yellow), deliver the desired chiral aldehydes with excellent enantioselectivity and good yields. M...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (28), p.5143-5147
Hauptverfasser: Mantilli, Luca, Gérard, David, Torche, Sonya, Besnard, Céline, Mazet, Clément
Format: Artikel
Sprache:eng
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allylic compounds
asymmetric catalysis
iridium
isomerization
P,N ligands
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container_end_page 5147
container_issue 28
container_start_page 5143
container_title Angewandte Chemie (International ed.)
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creator Mantilli, Luca
Gérard, David
Torche, Sonya
Besnard, Céline
Mazet, Clément
description Nothing to sm(Ir)k at: Under appropriate reaction conditions, iridium hydride catalysts promote the isomerization of primary allylic alcohols. The best catalysts, like (R)-1 (P green, O red, N blue, Ir yellow), deliver the desired chiral aldehydes with excellent enantioselectivity and good yields. Mechanistic hypotheses have been developed on the basis of preliminary investigations.
doi_str_mv 10.1002/anie.200901863
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source Wiley Online Library Journals Frontfile Complete
subjects allylic compounds
asymmetric catalysis
iridium
isomerization
P,N ligands
title Iridium-Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols
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