SNAT1 and a family with high rates of suicidal behavior
Abstract Several lines of evidence suggest that suicide may have, in part, a genetic predisposition. In this study, we identified a family with high rates of suicidal behavior and assessed brain gene expression levels in the proband. A neuronally-expressed solute carrier for glutamine (Sodium-couple...
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| Veröffentlicht in: | Neuroscience 2009-08, Vol.162 (2), p.415-422 |
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| creator | Ernst, C Dumoulin, P Cabot, S Erickson, J Turecki, G |
| description | Abstract Several lines of evidence suggest that suicide may have, in part, a genetic predisposition. In this study, we identified a family with high rates of suicidal behavior and assessed brain gene expression levels in the proband. A neuronally-expressed solute carrier for glutamine (Sodium-coupled neutral amino acid transporter 1 (SNAT1), also known as solute carrier family 38, member 1 (SLC38A1)) was identified as severely decreased across all brain regions. Follow-up analysis by semi-quantitative polymerase chain reaction (qPCR) and Western blot confirmed the reduction of SNAT1. We categorized the SNAT1 gene in human brain, cloned the gene promoter and assessed in silico the expression pattern of SNAT1 in >25 tissues from human. Complete DNA sequencing of the SNAT1 gene was performed in the family and 276 controls. The family was homozygous for rare alleles which suggests a possible association between low expression of SNAT1 and suicidal behavior. |
| doi_str_mv | 10.1016/j.neuroscience.2009.05.010 |
| format | Article |
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In this study, we identified a family with high rates of suicidal behavior and assessed brain gene expression levels in the proband. A neuronally-expressed solute carrier for glutamine (Sodium-coupled neutral amino acid transporter 1 (SNAT1), also known as solute carrier family 38, member 1 (SLC38A1)) was identified as severely decreased across all brain regions. Follow-up analysis by semi-quantitative polymerase chain reaction (qPCR) and Western blot confirmed the reduction of SNAT1. We categorized the SNAT1 gene in human brain, cloned the gene promoter and assessed in silico the expression pattern of SNAT1 in >25 tissues from human. Complete DNA sequencing of the SNAT1 gene was performed in the family and 276 controls. The family was homozygous for rare alleles which suggests a possible association between low expression of SNAT1 and suicidal behavior.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2009.05.010</identifier><identifier>PMID: 19442705</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Amino Acid Transport System A - biosynthesis ; Amino Acid Transport System A - genetics ; Biological and medical sciences ; Brain - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; glutamate metabolism ; Humans ; Male ; Medical sciences ; Middle Aged ; neurogenetics ; Neurology ; Oligonucleotide Array Sequence Analysis ; Pedigree ; Polymorphism, Single Nucleotide ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; SNAT1 ; Suicide ; Suicide - psychology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2009-08, Vol.162 (2), p.415-422</ispartof><rights>2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-63e34155fee1ab9bcd821e6263277eee842fd8cb63fd358eb4c1299cb86864643</citedby><cites>FETCH-LOGICAL-c494t-63e34155fee1ab9bcd821e6263277eee842fd8cb63fd358eb4c1299cb86864643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2009.05.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21727748$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19442705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ernst, C</creatorcontrib><creatorcontrib>Dumoulin, P</creatorcontrib><creatorcontrib>Cabot, S</creatorcontrib><creatorcontrib>Erickson, J</creatorcontrib><creatorcontrib>Turecki, G</creatorcontrib><title>SNAT1 and a family with high rates of suicidal behavior</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract Several lines of evidence suggest that suicide may have, in part, a genetic predisposition. In this study, we identified a family with high rates of suicidal behavior and assessed brain gene expression levels in the proband. A neuronally-expressed solute carrier for glutamine (Sodium-coupled neutral amino acid transporter 1 (SNAT1), also known as solute carrier family 38, member 1 (SLC38A1)) was identified as severely decreased across all brain regions. Follow-up analysis by semi-quantitative polymerase chain reaction (qPCR) and Western blot confirmed the reduction of SNAT1. We categorized the SNAT1 gene in human brain, cloned the gene promoter and assessed in silico the expression pattern of SNAT1 in >25 tissues from human. Complete DNA sequencing of the SNAT1 gene was performed in the family and 276 controls. The family was homozygous for rare alleles which suggests a possible association between low expression of SNAT1 and suicidal behavior.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Amino Acid Transport System A - biosynthesis</subject><subject>Amino Acid Transport System A - genetics</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>glutamate metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>neurogenetics</subject><subject>Neurology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Pedigree</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>SNAT1</subject><subject>Suicide</subject><subject>Suicide - psychology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhi0EokvhLyALCW4J42-HA1JVPqUKDi1ny3EmrJdsUuykaP89Xm0EiAv44svzzngeDyHPGNQMmH65q0dc0pRDxDFgzQGaGlQNDO6RDbNGVEZJeZ9sQICupOL8jDzKeQflKCkekjPWSMkNqA0x158ubhj1Y0c97f0-Dgf6I85buo1ftzT5GTOdepqXGGLnB9ri1t_FKT0mD3o_ZHyy3ufky7u3N5cfqqvP7z9eXlxVQTZyrrRAIZlSPSLzbdOGznKGmmvBjUFEK3nf2dBq0XdCWWxlYLxpQmu11VJLcU5enOrepun7gnl2-5gDDoMfcVqy00ZKa_m_wWJJG2N5AV-dwFAU5oS9u01x79PBMXBHv27n_vR7TDYOlCt-S_jp2mVp99j9jq5CC_B8BXwOfuiTH0PMvzjOTBlc2sK9OXFY5N1FTG5t18WEYXbdFP_vPa__KhOGOMbS-RseMO-mJY3lexxzmTtw18eNOC4ENACmyBc_AV3Psqc</recordid><startdate>20090818</startdate><enddate>20090818</enddate><creator>Ernst, C</creator><creator>Dumoulin, P</creator><creator>Cabot, S</creator><creator>Erickson, J</creator><creator>Turecki, G</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090818</creationdate><title>SNAT1 and a family with high rates of suicidal behavior</title><author>Ernst, C ; Dumoulin, P ; Cabot, S ; Erickson, J ; Turecki, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-63e34155fee1ab9bcd821e6263277eee842fd8cb63fd358eb4c1299cb86864643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Amino Acid Transport System A - biosynthesis</topic><topic>Amino Acid Transport System A - genetics</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>glutamate metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>neurogenetics</topic><topic>Neurology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Pedigree</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>SNAT1</topic><topic>Suicide</topic><topic>Suicide - psychology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ernst, C</creatorcontrib><creatorcontrib>Dumoulin, P</creatorcontrib><creatorcontrib>Cabot, S</creatorcontrib><creatorcontrib>Erickson, J</creatorcontrib><creatorcontrib>Turecki, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ernst, C</au><au>Dumoulin, P</au><au>Cabot, S</au><au>Erickson, J</au><au>Turecki, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SNAT1 and a family with high rates of suicidal behavior</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2009-08-18</date><risdate>2009</risdate><volume>162</volume><issue>2</issue><spage>415</spage><epage>422</epage><pages>415-422</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Abstract Several lines of evidence suggest that suicide may have, in part, a genetic predisposition. In this study, we identified a family with high rates of suicidal behavior and assessed brain gene expression levels in the proband. A neuronally-expressed solute carrier for glutamine (Sodium-coupled neutral amino acid transporter 1 (SNAT1), also known as solute carrier family 38, member 1 (SLC38A1)) was identified as severely decreased across all brain regions. Follow-up analysis by semi-quantitative polymerase chain reaction (qPCR) and Western blot confirmed the reduction of SNAT1. We categorized the SNAT1 gene in human brain, cloned the gene promoter and assessed in silico the expression pattern of SNAT1 in >25 tissues from human. Complete DNA sequencing of the SNAT1 gene was performed in the family and 276 controls. The family was homozygous for rare alleles which suggests a possible association between low expression of SNAT1 and suicidal behavior.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>19442705</pmid><doi>10.1016/j.neuroscience.2009.05.010</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Amino Acid Transport System A - biosynthesis Amino Acid Transport System A - genetics Biological and medical sciences Brain - metabolism Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease glutamate metabolism Humans Male Medical sciences Middle Aged neurogenetics Neurology Oligonucleotide Array Sequence Analysis Pedigree Polymorphism, Single Nucleotide Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry SNAT1 Suicide Suicide - psychology Vertebrates: nervous system and sense organs |
| title | SNAT1 and a family with high rates of suicidal behavior |
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