The Relationship of Phthalocyanine 4 (Pc 4) Concentrations Measured Noninvasively to Outcome of Pc 4 Photodynamic Therapy in Mice
The ability to noninvasively measure photosensitizer concentration at target tissues will allow optimization of photodynamic therapy (PDT) and could improve outcome. In this study, we evaluated whether preirradiation tumor phthalocyanine 4 (Pc 4) concentrations, measured noninvasively by the optical...
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| Veröffentlicht in: | Photochemistry and photobiology 2009-07, Vol.85 (4), p.1011-1019 |
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| creator | Bai, Lihua Guo, Jianxia Bontempo III, Franklin A. Eiseman, Julie L. |
| description | The ability to noninvasively measure photosensitizer concentration at target tissues will allow optimization of photodynamic therapy (PDT) and could improve outcome. In this study, we evaluated whether preirradiation tumor phthalocyanine 4 (Pc 4) concentrations, measured noninvasively by the optical pharmacokinetic system (OPS), correlated with tumor response to PDT. Mice bearing human breast cancer xenografts were treated with 2 mg kg−1 Pc 4 iv only, laser irradiation (150 J cm−2) only, Pc 4 followed by fractionated irradiation or Pc 4 followed by continuous irradiation. Laser irradiation treatment was initiated when the tumor to skin ratio of Pc 4 concentration reached a maximum of 2.1 at 48 h after administration. Pc 4 concentrations in tumor, as well as in Intralipid in vitro, decreased monoexponentially with laser fluence. Pc 4‐PDT resulted in significant tumor regression, and tumor response was similar in the groups receiving either fractionated or continuous irradiation treatment after Pc 4. Tumor growth delay following Pc 4‐PDT correlated with OPS‐measured tumor Pc 4 concentrations at 24 h prior to PDT (R2 = 0.86). In excised tumors, OPS‐measured Pc 4 concentrations were similar to the HPLC‐measured concentrations. Thus, OPS measurements of photosensitizer concentrations can be used to assist in the scheduling of Pc 4‐PDT. |
| doi_str_mv | 10.1111/j.1751-1097.2009.00542.x |
| format | Article |
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In this study, we evaluated whether preirradiation tumor phthalocyanine 4 (Pc 4) concentrations, measured noninvasively by the optical pharmacokinetic system (OPS), correlated with tumor response to PDT. Mice bearing human breast cancer xenografts were treated with 2 mg kg−1 Pc 4 iv only, laser irradiation (150 J cm−2) only, Pc 4 followed by fractionated irradiation or Pc 4 followed by continuous irradiation. Laser irradiation treatment was initiated when the tumor to skin ratio of Pc 4 concentration reached a maximum of 2.1 at 48 h after administration. Pc 4 concentrations in tumor, as well as in Intralipid in vitro, decreased monoexponentially with laser fluence. Pc 4‐PDT resulted in significant tumor regression, and tumor response was similar in the groups receiving either fractionated or continuous irradiation treatment after Pc 4. Tumor growth delay following Pc 4‐PDT correlated with OPS‐measured tumor Pc 4 concentrations at 24 h prior to PDT (R2 = 0.86). In excised tumors, OPS‐measured Pc 4 concentrations were similar to the HPLC‐measured concentrations. Thus, OPS measurements of photosensitizer concentrations can be used to assist in the scheduling of Pc 4‐PDT.</description><identifier>ISSN: 0031-8655</identifier><identifier>EISSN: 1751-1097</identifier><identifier>DOI: 10.1111/j.1751-1097.2009.00542.x</identifier><identifier>PMID: 19320848</identifier><identifier>CODEN: PHCBAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Apoptosis ; Breast Neoplasms - drug therapy ; Cancer ; Chromatography, High Pressure Liquid ; Female ; Humans ; Indoles - analysis ; Indoles - therapeutic use ; Mice ; Mice, SCID ; Photochemotherapy ; Photodynamic therapy ; Rodents ; Studies ; Transplantation, Heterologous</subject><ispartof>Photochemistry and photobiology, 2009-07, Vol.85 (4), p.1011-1019</ispartof><rights>2009 The Authors. Journal Compilation. The American Society of Photobiology</rights><rights>Copyright American Society for Photobiology Jul/Aug 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4312-d6caec86086bee792ea4c1a30f4fddd279403ed349f1d0e8af160d097f51c2d3</citedby><cites>FETCH-LOGICAL-c4312-d6caec86086bee792ea4c1a30f4fddd279403ed349f1d0e8af160d097f51c2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1751-1097.2009.00542.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1751-1097.2009.00542.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19320848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bai, Lihua</creatorcontrib><creatorcontrib>Guo, Jianxia</creatorcontrib><creatorcontrib>Bontempo III, Franklin A.</creatorcontrib><creatorcontrib>Eiseman, Julie L.</creatorcontrib><title>The Relationship of Phthalocyanine 4 (Pc 4) Concentrations Measured Noninvasively to Outcome of Pc 4 Photodynamic Therapy in Mice</title><title>Photochemistry and photobiology</title><addtitle>Photochem Photobiol</addtitle><description>The ability to noninvasively measure photosensitizer concentration at target tissues will allow optimization of photodynamic therapy (PDT) and could improve outcome. In this study, we evaluated whether preirradiation tumor phthalocyanine 4 (Pc 4) concentrations, measured noninvasively by the optical pharmacokinetic system (OPS), correlated with tumor response to PDT. Mice bearing human breast cancer xenografts were treated with 2 mg kg−1 Pc 4 iv only, laser irradiation (150 J cm−2) only, Pc 4 followed by fractionated irradiation or Pc 4 followed by continuous irradiation. Laser irradiation treatment was initiated when the tumor to skin ratio of Pc 4 concentration reached a maximum of 2.1 at 48 h after administration. Pc 4 concentrations in tumor, as well as in Intralipid in vitro, decreased monoexponentially with laser fluence. Pc 4‐PDT resulted in significant tumor regression, and tumor response was similar in the groups receiving either fractionated or continuous irradiation treatment after Pc 4. Tumor growth delay following Pc 4‐PDT correlated with OPS‐measured tumor Pc 4 concentrations at 24 h prior to PDT (R2 = 0.86). In excised tumors, OPS‐measured Pc 4 concentrations were similar to the HPLC‐measured concentrations. Thus, OPS measurements of photosensitizer concentrations can be used to assist in the scheduling of Pc 4‐PDT.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Cancer</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Female</subject><subject>Humans</subject><subject>Indoles - analysis</subject><subject>Indoles - therapeutic use</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Rodents</subject><subject>Studies</subject><subject>Transplantation, Heterologous</subject><issn>0031-8655</issn><issn>1751-1097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkctu1DAYRi0EotPCKyCLBSqLBDt2EkdiAyN6Qb2M6AjYWa79R-Mhiad2UiZL3ryeZlQkVnhjSz7f58tBCFOS0jg-rFNa5jShpCrTjJAqJSTnWbp9hmZPG8_RjBBGE1Hk-QE6DGFNCOVVSV-iA1qxjAguZujPcgX4GzSqt64LK7vBrsaLVb9SjdOj6mwHmOPjhcb8PZ67TkPX-wnGl6DC4MHgKxe5exXsPTQj7h2-HnrtWnjsislY6Hpnxk61VuN4olebEdsOX1oNr9CLWjUBXu_nI7Q8-bKcnyUX16fn808XieaMZokptAItCiKKW4CyykBxTRUjNa-NMVlZccLAMF7V1BAQqqYFMfEf6pzqzLAj9G6q3Xh3N0DoZWuDhqZRHbghyKLkXFDGI_j2H3DtBt_Fq8mMlRmvCi4iJCZIexeCh1puvG2VHyUlcqdIruXOhNyZkDtF8lGR3Mbom33_cNuC-RvcO4nAxwn4bRsY_7tYLs4WcRHjyRS3oYftU1z5X_GNrMzlj6tT-bP6_vVmefNZCvYAqrmu4w</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>Bai, Lihua</creator><creator>Guo, Jianxia</creator><creator>Bontempo III, Franklin A.</creator><creator>Eiseman, Julie L.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7TM</scope><scope>7U7</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>200907</creationdate><title>The Relationship of Phthalocyanine 4 (Pc 4) Concentrations Measured Noninvasively to Outcome of Pc 4 Photodynamic Therapy in Mice</title><author>Bai, Lihua ; Guo, Jianxia ; Bontempo III, Franklin A. ; Eiseman, Julie L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4312-d6caec86086bee792ea4c1a30f4fddd279403ed349f1d0e8af160d097f51c2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Cancer</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Female</topic><topic>Humans</topic><topic>Indoles - analysis</topic><topic>Indoles - therapeutic use</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy</topic><topic>Rodents</topic><topic>Studies</topic><topic>Transplantation, Heterologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Lihua</creatorcontrib><creatorcontrib>Guo, Jianxia</creatorcontrib><creatorcontrib>Bontempo III, Franklin A.</creatorcontrib><creatorcontrib>Eiseman, Julie L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Photochemistry and photobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Lihua</au><au>Guo, Jianxia</au><au>Bontempo III, Franklin A.</au><au>Eiseman, Julie L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship of Phthalocyanine 4 (Pc 4) Concentrations Measured Noninvasively to Outcome of Pc 4 Photodynamic Therapy in Mice</atitle><jtitle>Photochemistry and photobiology</jtitle><addtitle>Photochem Photobiol</addtitle><date>2009-07</date><risdate>2009</risdate><volume>85</volume><issue>4</issue><spage>1011</spage><epage>1019</epage><pages>1011-1019</pages><issn>0031-8655</issn><eissn>1751-1097</eissn><coden>PHCBAP</coden><abstract>The ability to noninvasively measure photosensitizer concentration at target tissues will allow optimization of photodynamic therapy (PDT) and could improve outcome. In this study, we evaluated whether preirradiation tumor phthalocyanine 4 (Pc 4) concentrations, measured noninvasively by the optical pharmacokinetic system (OPS), correlated with tumor response to PDT. Mice bearing human breast cancer xenografts were treated with 2 mg kg−1 Pc 4 iv only, laser irradiation (150 J cm−2) only, Pc 4 followed by fractionated irradiation or Pc 4 followed by continuous irradiation. Laser irradiation treatment was initiated when the tumor to skin ratio of Pc 4 concentration reached a maximum of 2.1 at 48 h after administration. Pc 4 concentrations in tumor, as well as in Intralipid in vitro, decreased monoexponentially with laser fluence. Pc 4‐PDT resulted in significant tumor regression, and tumor response was similar in the groups receiving either fractionated or continuous irradiation treatment after Pc 4. Tumor growth delay following Pc 4‐PDT correlated with OPS‐measured tumor Pc 4 concentrations at 24 h prior to PDT (R2 = 0.86). In excised tumors, OPS‐measured Pc 4 concentrations were similar to the HPLC‐measured concentrations. Thus, OPS measurements of photosensitizer concentrations can be used to assist in the scheduling of Pc 4‐PDT.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19320848</pmid><doi>10.1111/j.1751-1097.2009.00542.x</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Apoptosis Breast Neoplasms - drug therapy Cancer Chromatography, High Pressure Liquid Female Humans Indoles - analysis Indoles - therapeutic use Mice Mice, SCID Photochemotherapy Photodynamic therapy Rodents Studies Transplantation, Heterologous |
| title | The Relationship of Phthalocyanine 4 (Pc 4) Concentrations Measured Noninvasively to Outcome of Pc 4 Photodynamic Therapy in Mice |
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