Deficits in saccadic eye-movement control in Parkinson's disease
In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instruc...
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description | In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90–140
ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression. |
doi_str_mv | 10.1016/j.neuropsychologia.2004.06.026 |
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ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.</description><identifier>ISSN: 0028-3932</identifier><identifier>EISSN: 1873-3514</identifier><identifier>DOI: 10.1016/j.neuropsychologia.2004.06.026</identifier><identifier>PMID: 15721191</identifier><identifier>CODEN: NUPSA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Anti-saccades ; Attention - physiology ; Basal ganglia ; Biological and medical sciences ; Case-Control Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Express saccades ; Female ; Frontal cortex ; Gap effect ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Ocular Motility Disorders - etiology ; Organic mental disorders. Neuropsychology ; Parkinson Disease - physiopathology ; Photic Stimulation - methods ; Pro-saccades ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance - physiology ; Psychopathology. Psychiatry ; Reaction Time - physiology ; Saccades - physiology ; Task Performance and Analysis ; Time Factors</subject><ispartof>Neuropsychologia, 2005, Vol.43 (5), p.784-796</ispartof><rights>2004 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-98da114df60263a99b3fa8c7e9b87bf19de7e8e9a373a022b89f02a320624c003</citedby><cites>FETCH-LOGICAL-c486t-98da114df60263a99b3fa8c7e9b87bf19de7e8e9a373a022b89f02a320624c003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0028393204002064$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27902,27903,27904,65308</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16603453$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15721191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Florence</creatorcontrib><creatorcontrib>Armstrong, Irene T.</creatorcontrib><creatorcontrib>Pari, Giovanna</creatorcontrib><creatorcontrib>Riopelle, Richard J.</creatorcontrib><creatorcontrib>Munoz, Douglas P.</creatorcontrib><title>Deficits in saccadic eye-movement control in Parkinson's disease</title><title>Neuropsychologia</title><addtitle>Neuropsychologia</addtitle><description>In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90–140
ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-saccades</subject><subject>Attention - physiology</subject><subject>Basal ganglia</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Express saccades</subject><subject>Female</subject><subject>Frontal cortex</subject><subject>Gap effect</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Ocular Motility Disorders - etiology</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Photic Stimulation - methods</subject><subject>Pro-saccades</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Reaction Time - physiology</subject><subject>Saccades - physiology</subject><subject>Task Performance and Analysis</subject><subject>Time Factors</subject><issn>0028-3932</issn><issn>1873-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0E9v0zAYx3ELgVgpvAWUC-OU8NhO_eeCQNtgSJO2A5wtx3kCLold_KST-u5J1UqTOHHy5WP7py9jlxwaDlx92DYJ9yXv6BB-5TH_jL4RAG0DqgGhnrEVN1rWcsPb52wFIEwtrRQX7BXRFha4EeYlu-AbLTi3fMU-XeMQQ5ypiqkiH4LvY6jwgPWUH3HCNFchp7nk8QgefPkdE-X0nqo-EnrC1-zF4EfCN-dzzX58ufl-dVvf3X_9dvX5rg6tUXNtTe85b_tBLTOlt7aTgzdBo-2M7gZue9Ro0HqppQchOmMHEF4KUKINAHLNLk_v7kr-s0ea3RQp4Dj6hHlPTum21VqZBX48wVAyUcHB7UqcfDk4Du7Y0G3dvw3dsaED5Y7j1uzt-ad9N2H_dP0cbQHvzsBT8ONQfAqRnpxSINuNXNztyeHS5TFicRQipoB9LBhm1-f4v5v-Ah2EmjY</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Chan, Florence</creator><creator>Armstrong, Irene T.</creator><creator>Pari, Giovanna</creator><creator>Riopelle, Richard J.</creator><creator>Munoz, Douglas P.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Deficits in saccadic eye-movement control in Parkinson's disease</title><author>Chan, Florence ; Armstrong, Irene T. ; Pari, Giovanna ; Riopelle, Richard J. ; Munoz, Douglas P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-98da114df60263a99b3fa8c7e9b87bf19de7e8e9a373a022b89f02a320624c003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-saccades</topic><topic>Attention - physiology</topic><topic>Basal ganglia</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Express saccades</topic><topic>Female</topic><topic>Frontal cortex</topic><topic>Gap effect</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Ocular Motility Disorders - etiology</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Photic Stimulation - methods</topic><topic>Pro-saccades</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance - physiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Reaction Time - physiology</topic><topic>Saccades - physiology</topic><topic>Task Performance and Analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Florence</creatorcontrib><creatorcontrib>Armstrong, Irene T.</creatorcontrib><creatorcontrib>Pari, Giovanna</creatorcontrib><creatorcontrib>Riopelle, Richard J.</creatorcontrib><creatorcontrib>Munoz, Douglas P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropsychologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Florence</au><au>Armstrong, Irene T.</au><au>Pari, Giovanna</au><au>Riopelle, Richard J.</au><au>Munoz, Douglas P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deficits in saccadic eye-movement control in Parkinson's disease</atitle><jtitle>Neuropsychologia</jtitle><addtitle>Neuropsychologia</addtitle><date>2005</date><risdate>2005</risdate><volume>43</volume><issue>5</issue><spage>784</spage><epage>796</epage><pages>784-796</pages><issn>0028-3932</issn><eissn>1873-3514</eissn><coden>NUPSA6</coden><abstract>In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90–140
ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15721191</pmid><doi>10.1016/j.neuropsychologia.2004.06.026</doi><tpages>13</tpages></addata></record> |
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subjects | Adult Adult and adolescent clinical studies Aged Aged, 80 and over Anti-saccades Attention - physiology Basal ganglia Biological and medical sciences Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Express saccades Female Frontal cortex Gap effect Humans Male Medical sciences Middle Aged Neurology Ocular Motility Disorders - etiology Organic mental disorders. Neuropsychology Parkinson Disease - physiopathology Photic Stimulation - methods Pro-saccades Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - physiology Psychopathology. Psychiatry Reaction Time - physiology Saccades - physiology Task Performance and Analysis Time Factors |
title | Deficits in saccadic eye-movement control in Parkinson's disease |
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