PIK3CA mutations in advanced ovarian carcinomas

PIK3CA belongs to the phosphatidylinositol 3‐kinases (PI3Ks) family, which play an important role in proliferation, adherence, transformation and cell survival through the PI3K/AKT signaling pathway. Somatic activating mutations of this gene have recently been detected in several types of cancers. I...

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Veröffentlicht in:	Human mutation 2005-03, Vol.25 (3), p.322-322
Hauptverfasser:	Wang, Yun, Helland, Åslaug, Holm, Ruth, Kristensen, Gunnar B., Børresen-Dale, Anne-Lise
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Clear Cell - genetics Aged Carcinoma - genetics Carcinoma - mortality Cell Transformation, Neoplastic - genetics Class I Phosphatidylinositol 3-Kinases Cystadenocarcinoma, Mucinous - genetics Cystadenocarcinoma, Serous - genetics DNA Mutational Analysis Enzyme Activation - drug effects Exons - genetics Female Humans Life Tables Middle Aged Mutation, Missense ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Phosphatidylinositol 3-Kinases - genetics PIK3CA gene PIK3CA mutation Point Mutation Sequence Analysis, DNA Survival Rate
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