Ubiquitously expressed GPCR membrane-trafficking orthologs
Olfactory receptors are a diverse set of G-protein-coupled receptors (GPCRs) that localize to cellular plasma membranes in the olfactory epithelium. Associated trafficking proteins often assist in targeting these GPCRs to the membrane, facilitating function. One such trafficking protein has been iso...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 2005-03, Vol.85 (3), p.386-391 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Lehman, Chris W. Lee, Jaquelina D.R. Komives, Claire F. |
| description | Olfactory receptors are a diverse set of G-protein-coupled receptors (GPCRs) that localize to cellular plasma membranes in the olfactory epithelium. Associated trafficking proteins often assist in targeting these GPCRs to the membrane, facilitating function. One such trafficking protein has been isolated as a mutant defective for both odorant response and proper receptor localization in
Caenorhabditis elegans. This gene (ODR-4) allows for functional expression of olfactory receptors in heterologous cells that are otherwise incapable of targeting. We have isolated a full-length human cDNA that is homologous to the
C. elegans gene at the protein level across nearly the entire gene by using a novel RecA-based gene enrichment procedure. This sequence is homologous to a family of orthologs that share predicted structural features, indicating a conserved function. The gene was expressed in 41 of 44 human, mouse, and rat tissues, suggesting an important role in trafficking olfactory and other GPCRs. |
| doi_str_mv | 10.1016/j.ygeno.2004.11.009 |
| format | Article |
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Caenorhabditis elegans. This gene (ODR-4) allows for functional expression of olfactory receptors in heterologous cells that are otherwise incapable of targeting. We have isolated a full-length human cDNA that is homologous to the
C. elegans gene at the protein level across nearly the entire gene by using a novel RecA-based gene enrichment procedure. This sequence is homologous to a family of orthologs that share predicted structural features, indicating a conserved function. The gene was expressed in 41 of 44 human, mouse, and rat tissues, suggesting an important role in trafficking olfactory and other GPCRs.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/j.ygeno.2004.11.009</identifier><identifier>PMID: 15718105</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Caenorhabditis elegans ; cDNA ; Cell Membrane - metabolism ; Fundamental and applied biological sciences. Psychology ; Genes. Genome ; Genetics of eukaryotes. Biological and molecular evolution ; GPCR ; Humans ; Membrane trafficking ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Odorant ; ODR-4 ; ODR4 ; Olfactory ; Ortholog ; RecA ; Receptors, G-Protein-Coupled - chemistry ; Receptors, G-Protein-Coupled - metabolism ; Sequence conservation ; Sequence Homology, Amino Acid</subject><ispartof>Genomics (San Diego, Calif.), 2005-03, Vol.85 (3), p.386-391</ispartof><rights>2004 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-a916d58f477666b9d1bb426cb7d22a2b0d72c1cd3877062a47d4438be92542543</citedby><cites>FETCH-LOGICAL-c418t-a916d58f477666b9d1bb426cb7d22a2b0d72c1cd3877062a47d4438be92542543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ygeno.2004.11.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16630904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15718105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lehman, Chris W.</creatorcontrib><creatorcontrib>Lee, Jaquelina D.R.</creatorcontrib><creatorcontrib>Komives, Claire F.</creatorcontrib><title>Ubiquitously expressed GPCR membrane-trafficking orthologs</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>Olfactory receptors are a diverse set of G-protein-coupled receptors (GPCRs) that localize to cellular plasma membranes in the olfactory epithelium. Associated trafficking proteins often assist in targeting these GPCRs to the membrane, facilitating function. One such trafficking protein has been isolated as a mutant defective for both odorant response and proper receptor localization in
Caenorhabditis elegans. This gene (ODR-4) allows for functional expression of olfactory receptors in heterologous cells that are otherwise incapable of targeting. We have isolated a full-length human cDNA that is homologous to the
C. elegans gene at the protein level across nearly the entire gene by using a novel RecA-based gene enrichment procedure. This sequence is homologous to a family of orthologs that share predicted structural features, indicating a conserved function. The gene was expressed in 41 of 44 human, mouse, and rat tissues, suggesting an important role in trafficking olfactory and other GPCRs.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caenorhabditis elegans</subject><subject>cDNA</subject><subject>Cell Membrane - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes. Genome</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>GPCR</subject><subject>Humans</subject><subject>Membrane trafficking</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Odorant</subject><subject>ODR-4</subject><subject>ODR4</subject><subject>Olfactory</subject><subject>Ortholog</subject><subject>RecA</subject><subject>Receptors, G-Protein-Coupled - chemistry</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Sequence conservation</subject><subject>Sequence Homology, Amino Acid</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LE0EQhhtR3Bj9BYLkorcZq7p7unsED0vQVVhQxD03_VETO85kst0TMf_eiQnsTaGgLk-9vPUw9hKhRkD1dlsfN7Qbaw4ga8QaoH3EFgimrYyS6jFbgDGm0o0UV-xZKVuYCWH4U3aFjUaD0CzYuzuf7g9pGg-lP67o9z5TKRRXN1_X31YDDT67HVVTdl2Xws-026zGPP0Y-3FTnrMnnesLvbjsJbv7-OH7-lN1--Xm8_r6tgoSzVS5FlVsTCe1Vkr5NqL3kqvgdeTccQ9R84AhCqM1KO6kjlIK46nljZxHLNmbc-4-j_cHKpMdUgnU93OzubZVWkolDPwXRG1QguAzKM5gyGMpmTq7z2lw-WgR7Mmt3dq_bu3JrUW0J3NL9uoSf_ADxYebi8wZeH0BXAmu72Z1IZUHTikBLZween_maLb2K1G2JSTaBYopU5hsHNM_i_wB1jmXYw</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Lehman, Chris W.</creator><creator>Lee, Jaquelina D.R.</creator><creator>Komives, Claire F.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Ubiquitously expressed GPCR membrane-trafficking orthologs</title><author>Lehman, Chris W. ; Lee, Jaquelina D.R. ; Komives, Claire F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-a916d58f477666b9d1bb426cb7d22a2b0d72c1cd3877062a47d4438be92542543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Caenorhabditis elegans</topic><topic>cDNA</topic><topic>Cell Membrane - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes. Genome</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>GPCR</topic><topic>Humans</topic><topic>Membrane trafficking</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Odorant</topic><topic>ODR-4</topic><topic>ODR4</topic><topic>Olfactory</topic><topic>Ortholog</topic><topic>RecA</topic><topic>Receptors, G-Protein-Coupled - chemistry</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Sequence conservation</topic><topic>Sequence Homology, Amino Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lehman, Chris W.</creatorcontrib><creatorcontrib>Lee, Jaquelina D.R.</creatorcontrib><creatorcontrib>Komives, Claire F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lehman, Chris W.</au><au>Lee, Jaquelina D.R.</au><au>Komives, Claire F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ubiquitously expressed GPCR membrane-trafficking orthologs</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>85</volume><issue>3</issue><spage>386</spage><epage>391</epage><pages>386-391</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>Olfactory receptors are a diverse set of G-protein-coupled receptors (GPCRs) that localize to cellular plasma membranes in the olfactory epithelium. Associated trafficking proteins often assist in targeting these GPCRs to the membrane, facilitating function. One such trafficking protein has been isolated as a mutant defective for both odorant response and proper receptor localization in
Caenorhabditis elegans. This gene (ODR-4) allows for functional expression of olfactory receptors in heterologous cells that are otherwise incapable of targeting. We have isolated a full-length human cDNA that is homologous to the
C. elegans gene at the protein level across nearly the entire gene by using a novel RecA-based gene enrichment procedure. This sequence is homologous to a family of orthologs that share predicted structural features, indicating a conserved function. The gene was expressed in 41 of 44 human, mouse, and rat tissues, suggesting an important role in trafficking olfactory and other GPCRs.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>15718105</pmid><doi>10.1016/j.ygeno.2004.11.009</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Caenorhabditis elegans cDNA Cell Membrane - metabolism Fundamental and applied biological sciences. Psychology Genes. Genome Genetics of eukaryotes. Biological and molecular evolution GPCR Humans Membrane trafficking Molecular and cellular biology Molecular genetics Molecular Sequence Data Odorant ODR-4 ODR4 Olfactory Ortholog RecA Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - metabolism Sequence conservation Sequence Homology, Amino Acid |
| title | Ubiquitously expressed GPCR membrane-trafficking orthologs |
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