Generating Genetic Risk Scores from Intermediate Phenotypes for Use in Association Studies of Clinically Significant Endpoints

Summary While previous results of genetic association studies for common, complex diseases (eg., coronary artery disease, CAD) have been disappointing, examination of multiple related genes within a physiologic pathway may provide improved resolution. This paper describes a method of calculating a g...

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Veröffentlicht in:	Annals of human genetics 2005-03, Vol.69 (2), p.176-186
Hauptverfasser:	Horne, B. D., Anderson, J. L., Carlquist, J. F., Muhlestein, J. B., Renlund, D. G., Bair, T. L., Pearson, R. R., Camp, N. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Coronary Disease - genetics Female Genetic Burden Genetic Predisposition to Disease Humans Male Phenotype Polygenic Traits Polymorphism, Single Nucleotide Risk Assessment
Online-Zugang:	Volltext
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