The Effect of Age on the Association Between Blood Pressure and Cognitive Function Later in Life
OBJECTIVES: To determine the prospective relationship between blood pressure (BP) and cognitive function across a wide age range. DESIGN: Prospective population‐based cohort study. SETTING: The Rotterdam Study and the Leiden 85‐plus Study. PARTICIPANTS: Three thousand seventy‐eight men and women, in...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2009-07, Vol.57 (7), p.1232-1237 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | Euser, Sjoerd M. Van Bemmel, Thomas Schram, Miranda T. Gussekloo, Jacobijn Hofman, Albert Westendorp, Rudi G. J. Breteler, Monique M. B. |
| description | OBJECTIVES: To determine the prospective relationship between blood pressure (BP) and cognitive function across a wide age range.
DESIGN: Prospective population‐based cohort study.
SETTING: The Rotterdam Study and the Leiden 85‐plus Study.
PARTICIPANTS: Three thousand seventy‐eight men and women, initial age 55 to 84 from the Rotterdam Study and 276 men and women, initial age 85, from the Leiden 85‐plus Study.
MEASUREMENTS: Systolic BP (SBP) and diastolic BP (DBP) were measured at baseline, cognitive function was assessed at the end of follow‐up using a dedicated neuropsychological test battery. The association between baseline BP levels and cognitive function later in life was assessed in 10‐year age groups in the Rotterdam Study and in 85‐year‐olds of the Leiden 85‐plus Study.
RESULTS: In the youngest participants ( |
| doi_str_mv | 10.1111/j.1532-5415.2009.02264.x |
| format | Article |
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DESIGN: Prospective population‐based cohort study.
SETTING: The Rotterdam Study and the Leiden 85‐plus Study.
PARTICIPANTS: Three thousand seventy‐eight men and women, initial age 55 to 84 from the Rotterdam Study and 276 men and women, initial age 85, from the Leiden 85‐plus Study.
MEASUREMENTS: Systolic BP (SBP) and diastolic BP (DBP) were measured at baseline, cognitive function was assessed at the end of follow‐up using a dedicated neuropsychological test battery. The association between baseline BP levels and cognitive function later in life was assessed in 10‐year age groups in the Rotterdam Study and in 85‐year‐olds of the Leiden 85‐plus Study.
RESULTS: In the youngest participants (<65), SBP and DBP were not associated with cognitive function 11 years later. For persons aged 65 to 74, higher baseline SBP and DBP were related to worse cognitive function 11 years later. In contrast, in older age (≥75), higher SBP and DBP seemed to be related to better cognitive function at the end of follow‐up. This effect appeared strongest in the highest age group (aged 85).
CONCLUSION: High BP was associated with greater risk of cognitive impairment in persons younger than 75 but with better cognitive function in older persons. Age‐specific guidelines for BP management are needed, because the current directive that “lower is better” may not apply to BP levels in the very old.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2009.02264.x</identifier><identifier>PMID: 19453303</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Age ; Age Factors ; Aged ; Aged, 80 and over ; Aging - physiology ; Biological and medical sciences ; Blood pressure ; Cognition & reasoning ; Cognition Disorders - epidemiology ; Cognition Disorders - physiopathology ; cognitive function ; Female ; General aspects ; Geriatric Assessment ; Humans ; Hypertension - epidemiology ; Hypertension - physiopathology ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Netherlands - epidemiology ; Neuropsychological Tests ; Older people ; prospective cohort study ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2009-07, Vol.57 (7), p.1232-1237</ispartof><rights>2009, Copyright the Authors. Journal compilation © 2009, The American Geriatrics Society</rights><rights>2009 INIST-CNRS</rights><rights>Journal compilation 2009 The American Geriatrics Society/Blackwell Publishing</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4894-8283b65925252fb1e2376bde4de279c8a0a9461715c1de879ee9fec51332e7683</citedby><cites>FETCH-LOGICAL-c4894-8283b65925252fb1e2376bde4de279c8a0a9461715c1de879ee9fec51332e7683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-5415.2009.02264.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-5415.2009.02264.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21724754$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19453303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Euser, Sjoerd M.</creatorcontrib><creatorcontrib>Van Bemmel, Thomas</creatorcontrib><creatorcontrib>Schram, Miranda T.</creatorcontrib><creatorcontrib>Gussekloo, Jacobijn</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Westendorp, Rudi G. J.</creatorcontrib><creatorcontrib>Breteler, Monique M. B.</creatorcontrib><title>The Effect of Age on the Association Between Blood Pressure and Cognitive Function Later in Life</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>OBJECTIVES: To determine the prospective relationship between blood pressure (BP) and cognitive function across a wide age range.
DESIGN: Prospective population‐based cohort study.
SETTING: The Rotterdam Study and the Leiden 85‐plus Study.
PARTICIPANTS: Three thousand seventy‐eight men and women, initial age 55 to 84 from the Rotterdam Study and 276 men and women, initial age 85, from the Leiden 85‐plus Study.
MEASUREMENTS: Systolic BP (SBP) and diastolic BP (DBP) were measured at baseline, cognitive function was assessed at the end of follow‐up using a dedicated neuropsychological test battery. The association between baseline BP levels and cognitive function later in life was assessed in 10‐year age groups in the Rotterdam Study and in 85‐year‐olds of the Leiden 85‐plus Study.
RESULTS: In the youngest participants (<65), SBP and DBP were not associated with cognitive function 11 years later. For persons aged 65 to 74, higher baseline SBP and DBP were related to worse cognitive function 11 years later. In contrast, in older age (≥75), higher SBP and DBP seemed to be related to better cognitive function at the end of follow‐up. This effect appeared strongest in the highest age group (aged 85).
CONCLUSION: High BP was associated with greater risk of cognitive impairment in persons younger than 75 but with better cognitive function in older persons. Age‐specific guidelines for BP management are needed, because the current directive that “lower is better” may not apply to BP levels in the very old.</description><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - physiopathology</subject><subject>cognitive function</subject><subject>Female</subject><subject>General aspects</subject><subject>Geriatric Assessment</subject><subject>Humans</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Netherlands - epidemiology</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>prospective cohort study</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vEzEQhi0EomnhLyALCW67-HPtPXAIoQ2gqIBa1KNxvLPFYbMu9m6b_nucJgoSF7APM7afdzSeFyFMSUnzerMqqeSskILKkhFSl4SxSpSbR2hyeHiMJoQQVuiKiiN0nNKKEMqI1k_REa2F5JzwCfp--QPwaduCG3Bo8fQacOjxkC-nKQXn7eDz-R0MdwA5diE0-EuElMYI2PYNnoXr3g_-FvDZ2LsHemEHiNjnxLfwDD1pbZfg-T6eoG9np5ezD8Xi8_zjbLoonNC1KDTTfFnJmsm82yUFxlW1bEA0wFTttCW2FhVVVDragFY1QJ2blpRzBqrS_AS93tW9ieHXCGkwa58cdJ3tIYzJVEoIXiv2T5DlWRJSkQy-_AtchTH2-ROGUcI1VURmSO8gF0NKEVpzE_3axntDidl6ZVZma4nZWmK2XpkHr8wmS1_s64_LNTR_hHtzMvBqD9jkbNdG2zufDhyjigklRebe7rg738H9fzdgPs0vtlnWFzu9TwNsDnobf-apcSXN1fncXEj5_nx29dUw_hsLJrt_</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>Euser, Sjoerd M.</creator><creator>Van Bemmel, Thomas</creator><creator>Schram, Miranda T.</creator><creator>Gussekloo, Jacobijn</creator><creator>Hofman, Albert</creator><creator>Westendorp, Rudi G. J.</creator><creator>Breteler, Monique M. B.</creator><general>Blackwell Publishing Inc</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200907</creationdate><title>The Effect of Age on the Association Between Blood Pressure and Cognitive Function Later in Life</title><author>Euser, Sjoerd M. ; Van Bemmel, Thomas ; Schram, Miranda T. ; Gussekloo, Jacobijn ; Hofman, Albert ; Westendorp, Rudi G. J. ; Breteler, Monique M. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4894-8283b65925252fb1e2376bde4de279c8a0a9461715c1de879ee9fec51332e7683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - physiopathology</topic><topic>cognitive function</topic><topic>Female</topic><topic>General aspects</topic><topic>Geriatric Assessment</topic><topic>Humans</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Netherlands - epidemiology</topic><topic>Neuropsychological Tests</topic><topic>Older people</topic><topic>prospective cohort study</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Euser, Sjoerd M.</creatorcontrib><creatorcontrib>Van Bemmel, Thomas</creatorcontrib><creatorcontrib>Schram, Miranda T.</creatorcontrib><creatorcontrib>Gussekloo, Jacobijn</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Westendorp, Rudi G. J.</creatorcontrib><creatorcontrib>Breteler, Monique M. B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Euser, Sjoerd M.</au><au>Van Bemmel, Thomas</au><au>Schram, Miranda T.</au><au>Gussekloo, Jacobijn</au><au>Hofman, Albert</au><au>Westendorp, Rudi G. J.</au><au>Breteler, Monique M. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Age on the Association Between Blood Pressure and Cognitive Function Later in Life</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2009-07</date><risdate>2009</risdate><volume>57</volume><issue>7</issue><spage>1232</spage><epage>1237</epage><pages>1232-1237</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>OBJECTIVES: To determine the prospective relationship between blood pressure (BP) and cognitive function across a wide age range.
DESIGN: Prospective population‐based cohort study.
SETTING: The Rotterdam Study and the Leiden 85‐plus Study.
PARTICIPANTS: Three thousand seventy‐eight men and women, initial age 55 to 84 from the Rotterdam Study and 276 men and women, initial age 85, from the Leiden 85‐plus Study.
MEASUREMENTS: Systolic BP (SBP) and diastolic BP (DBP) were measured at baseline, cognitive function was assessed at the end of follow‐up using a dedicated neuropsychological test battery. The association between baseline BP levels and cognitive function later in life was assessed in 10‐year age groups in the Rotterdam Study and in 85‐year‐olds of the Leiden 85‐plus Study.
RESULTS: In the youngest participants (<65), SBP and DBP were not associated with cognitive function 11 years later. For persons aged 65 to 74, higher baseline SBP and DBP were related to worse cognitive function 11 years later. In contrast, in older age (≥75), higher SBP and DBP seemed to be related to better cognitive function at the end of follow‐up. This effect appeared strongest in the highest age group (aged 85).
CONCLUSION: High BP was associated with greater risk of cognitive impairment in persons younger than 75 but with better cognitive function in older persons. Age‐specific guidelines for BP management are needed, because the current directive that “lower is better” may not apply to BP levels in the very old.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>19453303</pmid><doi>10.1111/j.1532-5415.2009.02264.x</doi><tpages>6</tpages></addata></record> |
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| issn | 0002-8614 1532-5415 |
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| source | MEDLINE; Wiley Blackwell Single Titles |
| subjects | Age Age Factors Aged Aged, 80 and over Aging - physiology Biological and medical sciences Blood pressure Cognition & reasoning Cognition Disorders - epidemiology Cognition Disorders - physiopathology cognitive function Female General aspects Geriatric Assessment Humans Hypertension - epidemiology Hypertension - physiopathology Male Medical sciences Middle Aged Miscellaneous Netherlands - epidemiology Neuropsychological Tests Older people prospective cohort study Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine |
| title | The Effect of Age on the Association Between Blood Pressure and Cognitive Function Later in Life |
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