The dissipation of neuropathic pain paradoxically involves the presence of tumor necrosis factor-α (TNF)

Neuropathic pain, a chronic disabling pain arising from nerve injury, develops a central component. In brain neurons, tumor necrosis factor-α (TNF) levels intensify and TNF-inhibition of norepinephrine (NE) release, dependent upon α 2-adrenergic activation, amplifies during neuropathic pain onset. T...

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Veröffentlicht in:	Neuropharmacology 2005-03, Vol.48 (3), p.448-460
Hauptverfasser:	Ignatowski, Tracey A., Sud, Reeteka, Reynolds, Jessica L., Knight, Paul R., Spengler, Robert N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressant Dose-Response Relationship, Drug Hyperalgesia Male Neuropathic pain Norepinephrine Norepinephrine - metabolism Pain - drug therapy Pain - metabolism Pain Measurement - drug effects Pain Measurement - methods Rats Rats, Sprague-Dawley Sciatic Neuropathy - drug therapy Sciatic Neuropathy - metabolism Tumor necrosis factor Tumor Necrosis Factor-alpha - physiology Tumor Necrosis Factor-alpha - therapeutic use α 2-Adrenergic receptor
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