Combined Survival Analysis of Prospective Clinical Trials of Gefitinib for Non–Small Cell Lung Cancer with EGFR Mutations

Purpose: Somatic mutations of the epidermal growth factor receptor ( EGFR ) gene are associated with an increased response to gefitinib in patients with non–small cell lung cancer. We have examined the impact of gefitinib on progression-free survival and overall survival in patients with EGFR mutati...

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Veröffentlicht in:	Clinical cancer research 2009-07, Vol.15 (13), p.4493-4498
Hauptverfasser:	MORITA, Satoshi, OKAMOTO, Isamu, YOSHIDA, Kimihide, HIRASHIMA, Tomonori, YASUMOTO, Kosei, SUGIO, Kenji, MITSUDOMI, Tetsuya, FUKUOKA, Masahiro, NUKIWA, Toshihiro, KOBAYASHI, Kunihiko, YAMAZAKI, Koichi, ASAHINA, Hajime, INOUE, Akira, HAGIWARA, Koichi, SUNAGA, Noriaki, YANAGITANI, Noriko, HIDA, Toyoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Clinical Trials, Phase II as Topic EGF receptor Female gefitinib Genes, erbB-1 Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Male Medical sciences Middle Aged mutation Mutation - physiology non–small cell lung cancer Pharmacology. Drug treatments Pneumology Quinazolines - therapeutic use Survival Analysis Treatment Outcome Tumors of the respiratory system and mediastinum
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