Selective induction of cell cycle arrest and apoptosis in human prostate cancer cells through adenoviral transfer of the melanoma differentiation-associated −7 (mda-7)/interleukin-24 (IL-24) gene

We have previously reported that overexpression of the melanoma differentiation-associated gene -7 ( mda-7 ) using a replication-defective adenovirus (Ad-mda7), results in tumor-specific growth suppression and induction of apoptosis in wide variety of cancer cells. In the present study, we investiga...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer gene therapy 2005-03, Vol.12 (3), p.238-247
Hauptverfasser:	Saito, Yuji, Miyahara, Ryo, Gopalan, Began, Litvak, Anya, Inoue, Satoshi, Shanker, Manish, Branch, Cynthia D, Mhashilkar, Abner M, Roth, Jack A, Chada, Sunil, Ramesh, Rajagopal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenovirus Analysis of Variance Annexin A5 - metabolism Antitumor activity Apoptosis Apoptosis - drug effects Apoptosis - genetics Biomedical and Life Sciences Biomedicine Care and treatment Caspase Cell cycle Cell Cycle - drug effects Cell Cycle - genetics Cell Proliferation Diagnosis Epithelial cells Flow Cytometry G2 phase Gene Expression Gene Expression Regulation, Neoplastic - drug effects Gene Therapy Gene Transfer Techniques Genes, Tumor Suppressor Genetic aspects Genetic Therapy - methods Genetic Vectors Humans Immunoblotting Interleukin 24 Interleukins Interleukins - genetics Interleukins - pharmacology Male Mda-7 protein Melanoma original-article Physiological aspects Prostate cancer Prostatic Neoplasms - therapy Risk factors Tumor cells Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!