Eplerenone Blocks Nongenomic Effects of Aldosterone on the Na+/H+ Exchanger, Intracellular Ca2+ Levels, and Vasoconstriction in Mesenteric Resistance Vessels

There is increasing evidence for rapid nongenomic effects of aldosterone. Aldosterone has been demonstrated to alter intracellular pH and calcium in isolated cells. However, few studies have correlated these effects with aldosterone-mediated physiological responses. Therefore, we studied rapid effec...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2005-03, Vol.146 (3), p.973-980
Hauptverfasser:	Michea, Luis, Delpiano, Ana M, Hitschfeld, Catalina, Lobos, Lorena, Lavandero, Sergio, Marusic, Elisa T
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Aldosterone Aldosterone - metabolism Amiloride Androstadienes - pharmacology Animals Arteries Blotting, Western Ca2+/H+-exchanging ATPase Calcium (intracellular) Calcium - metabolism Calcium ions Chromones - pharmacology Constrictions Contractility Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Hydrogen-Ion Concentration Indoles - pharmacology Intracellular Kinases Male Maleimides - pharmacology Mesenteric Arteries - drug effects Mineralocorticoid Receptor Antagonists Morpholines - pharmacology Na+/Ca2+ exchanger Na+/H+-exchanging ATPase p38 Mitogen-Activated Protein Kinases - metabolism pH effects Phenylephrine Phenylephrine - pharmacology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physiological effects Physiological responses Protein kinase C Protein Kinase C - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Rats, Sprague-Dawley Sodium Sodium-Hydrogen Exchanger 1 Sodium-Hydrogen Exchangers - metabolism Spironolactone - analogs & derivatives Spironolactone - pharmacology Time Factors Vascular tissue Vasoconstriction Wortmannin
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