Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice
Beneficial effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) on the development and function of the central nervous system are well documented. In spite of primary deficiency of GH and secondary IGF-1 deficiency, Ames dwarf mice live considerably longer than normal animals, exh...
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| Veröffentlicht in: | Neurobiology of aging 2005-06, Vol.26 (6), p.929-937 |
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| creator | Sun, Liou Y. Al-Regaiey, Khalid Masternak, Michal M. Wang, Jian Bartke, Andrzej |
| description | Beneficial effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) on the development and function of the central nervous system are well documented. In spite of primary deficiency of GH and secondary IGF-1 deficiency, Ames dwarf mice live considerably longer than normal animals, exhibit apparently normal cognitive functions and maintain them into advanced age. In an attempt to reconcile these findings, we have examined local expression of GH and IGF-1 in the hippocampus of normal and Ames dwarf mice. We found that both hippocampal GH and IGF-1 protein levels are increased and the corresponding mRNAs are normal in Ames dwarf as compared with normal mice. Increased phosphorylation of Akt and cyclic AMP responsive element-binding protein (CREB) were detected in the hippocampus of Ames dwarf mice. Our results suggest that increase in hippocampal GH and IGF-1 protein expression and subsequent activation of PI3K/Akt-CREB signal transduction cascade might contribute to the maintenance of cognitive function and is likely to be responsible for the integrity of neuronal structure, and maintenance of youthful levels of cognitive function in these long-lived mice during aging. |
| doi_str_mv | 10.1016/j.neurobiolaging.2004.07.010 |
| format | Article |
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In spite of primary deficiency of GH and secondary IGF-1 deficiency, Ames dwarf mice live considerably longer than normal animals, exhibit apparently normal cognitive functions and maintain them into advanced age. In an attempt to reconcile these findings, we have examined local expression of GH and IGF-1 in the hippocampus of normal and Ames dwarf mice. We found that both hippocampal GH and IGF-1 protein levels are increased and the corresponding mRNAs are normal in Ames dwarf as compared with normal mice. Increased phosphorylation of Akt and cyclic AMP responsive element-binding protein (CREB) were detected in the hippocampus of Ames dwarf mice. Our results suggest that increase in hippocampal GH and IGF-1 protein expression and subsequent activation of PI3K/Akt-CREB signal transduction cascade might contribute to the maintenance of cognitive function and is likely to be responsible for the integrity of neuronal structure, and maintenance of youthful levels of cognitive function in these long-lived mice during aging.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2004.07.010</identifier><identifier>PMID: 15718052</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Dwarfism - metabolism ; Fundamental and applied biological sciences. Psychology ; Growth Hormone - deficiency ; Growth Hormone - metabolism ; Hippocampus ; Hippocampus - metabolism ; IGF-1 ; Insulin-Like Growth Factor I - deficiency ; Insulin-Like Growth Factor I - metabolism ; Life Expectancy ; Longevity - physiology ; Male ; Mice ; Mitogen-Activated Protein Kinases - metabolism ; Phosphatidylinositol 3-Kinases - metabolism ; Protein-Serine-Threonine Kinases - metabolism ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-akt ; Signal Transduction - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurobiology of aging, 2005-06, Vol.26 (6), p.929-937</ispartof><rights>2004 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-1ac2cd1a35a86bdfb8f320d3b7d77239a566a8e8d079e0eb3324c7ecfa12c17f3</citedby><cites>FETCH-LOGICAL-c480t-1ac2cd1a35a86bdfb8f320d3b7d77239a566a8e8d079e0eb3324c7ecfa12c17f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458004002842$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16558593$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15718052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Liou Y.</creatorcontrib><creatorcontrib>Al-Regaiey, Khalid</creatorcontrib><creatorcontrib>Masternak, Michal M.</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Bartke, Andrzej</creatorcontrib><title>Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Beneficial effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) on the development and function of the central nervous system are well documented. In spite of primary deficiency of GH and secondary IGF-1 deficiency, Ames dwarf mice live considerably longer than normal animals, exhibit apparently normal cognitive functions and maintain them into advanced age. In an attempt to reconcile these findings, we have examined local expression of GH and IGF-1 in the hippocampus of normal and Ames dwarf mice. We found that both hippocampal GH and IGF-1 protein levels are increased and the corresponding mRNAs are normal in Ames dwarf as compared with normal mice. Increased phosphorylation of Akt and cyclic AMP responsive element-binding protein (CREB) were detected in the hippocampus of Ames dwarf mice. Our results suggest that increase in hippocampal GH and IGF-1 protein expression and subsequent activation of PI3K/Akt-CREB signal transduction cascade might contribute to the maintenance of cognitive function and is likely to be responsible for the integrity of neuronal structure, and maintenance of youthful levels of cognitive function in these long-lived mice during aging.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Dwarfism - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Hormone - deficiency</subject><subject>Growth Hormone - metabolism</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>IGF-1</subject><subject>Insulin-Like Growth Factor I - deficiency</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Life Expectancy</subject><subject>Longevity - physiology</subject><subject>Male</subject><subject>Mice</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-akt</subject><subject>Signal Transduction - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0UFv0zAUwHELgVg3-ArIB-CW8BwnsSNxQRPtJlXiAJwtx37uXCVxsJNpfHtctdK0Gydffu_Z-puQjwxKBqz9ciwnXGPofRj0wU-HsgKoSxAlMHhFNqxpZMHqTrwmG2CdKOpGwhW5TukIAKIW7VtyxRrBJDTVhvzcB6MHik9zxJR8mGhwdHdH9WTp_W5bMOonujwgffDznOk4r-lMCovOG4_TQocwHYrBP6Klozf4jrxxekj4_nLekN_b779u74r9j9397bd9YWoJS8G0qYxlmjdatr11vXS8Ast7YYWoeKebttUSpQXRIWDPeVUbgcZpVhkmHL8hn8975xj-rJgWNfpkcBj0hGFNqhU1l5LVGX49QxNDShGdmqMfdfyrGKhTVHVUL6OqU1QFQuWoefzD5Z61H9E-D18qZvDpAnTKNV3Uk_Hp2bX5T5qOZ7c9O8xVHj1GlU4BDVof0SzKBv9_L_oH5sqdbg</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Sun, Liou Y.</creator><creator>Al-Regaiey, Khalid</creator><creator>Masternak, Michal M.</creator><creator>Wang, Jian</creator><creator>Bartke, Andrzej</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice</title><author>Sun, Liou Y. ; Al-Regaiey, Khalid ; Masternak, Michal M. ; Wang, Jian ; Bartke, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-1ac2cd1a35a86bdfb8f320d3b7d77239a566a8e8d079e0eb3324c7ecfa12c17f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Dwarfism - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Hormone - deficiency</topic><topic>Growth Hormone - metabolism</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>IGF-1</topic><topic>Insulin-Like Growth Factor I - deficiency</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Life Expectancy</topic><topic>Longevity - physiology</topic><topic>Male</topic><topic>Mice</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-akt</topic><topic>Signal Transduction - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Liou Y.</creatorcontrib><creatorcontrib>Al-Regaiey, Khalid</creatorcontrib><creatorcontrib>Masternak, Michal M.</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Bartke, Andrzej</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Liou Y.</au><au>Al-Regaiey, Khalid</au><au>Masternak, Michal M.</au><au>Wang, Jian</au><au>Bartke, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>26</volume><issue>6</issue><spage>929</spage><epage>937</epage><pages>929-937</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Beneficial effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) on the development and function of the central nervous system are well documented. In spite of primary deficiency of GH and secondary IGF-1 deficiency, Ames dwarf mice live considerably longer than normal animals, exhibit apparently normal cognitive functions and maintain them into advanced age. In an attempt to reconcile these findings, we have examined local expression of GH and IGF-1 in the hippocampus of normal and Ames dwarf mice. We found that both hippocampal GH and IGF-1 protein levels are increased and the corresponding mRNAs are normal in Ames dwarf as compared with normal mice. Increased phosphorylation of Akt and cyclic AMP responsive element-binding protein (CREB) were detected in the hippocampus of Ames dwarf mice. Our results suggest that increase in hippocampal GH and IGF-1 protein expression and subsequent activation of PI3K/Akt-CREB signal transduction cascade might contribute to the maintenance of cognitive function and is likely to be responsible for the integrity of neuronal structure, and maintenance of youthful levels of cognitive function in these long-lived mice during aging.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>15718052</pmid><doi>10.1016/j.neurobiolaging.2004.07.010</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Dwarfism - metabolism Fundamental and applied biological sciences. Psychology Growth Hormone - deficiency Growth Hormone - metabolism Hippocampus Hippocampus - metabolism IGF-1 Insulin-Like Growth Factor I - deficiency Insulin-Like Growth Factor I - metabolism Life Expectancy Longevity - physiology Male Mice Mitogen-Activated Protein Kinases - metabolism Phosphatidylinositol 3-Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Signal Transduction - physiology Vertebrates: nervous system and sense organs |
| title | Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice |
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