Genome-wide association studies: theoretical and practical concerns

Key Points Recent improvements in genotyping technology and in our knowledge of human genetic variation have made it possible to carry out genome-wide genetic association studies to identify susceptibility genes for common disease. However, before such studies are undertaken, it is important to know...

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Veröffentlicht in:	Nature reviews. Genetics 2005-02, Vol.6 (2), p.109-118
Hauptverfasser:	Wang, William Y. S., Barratt, Bryan J., Clayton, David G., Todd, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Computational Biology - methods Confounding (Statistics) Cost control Diabetes Disease Fundamental and applied biological sciences. Psychology Gene Function Genes Genetic Predisposition to Disease - genetics Genetics of eukaryotes. Biological and molecular evolution Genome Genomes Genomics Human Genetics Humans Linkage Disequilibrium - genetics Models, Genetic Polymorphism, Single Nucleotide - genetics R&D Ratios Research & development review-article Sample size Sequence Analysis, DNA - methods Statistical power
Online-Zugang:	Volltext
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