Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression

Tylophorine, a representative phenanthroindolizidine alkaloid from Tylophoraindica plants, exhibits anti-inflammatory and anti-cancerous growth activities. However, the underlying mechanisms of its anti-cancer activity have not been elucidated and its effects on cell cycle remain ambiguous. Here, we...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-08, Vol.386 (1), p.140-145
Hauptverfasser:	Wu, Chia-Mao, Yang, Cheng-Wei, Lee, Yue-Zhi, Chuang, Ta-Hsien, Wu, Pei-Lin, Chao, Yu-Sheng, Lee, Shiow-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Antineoplastic Agents - pharmacology Carcinoma - metabolism Carcinoma cells Cell Line, Tumor Cyclin A - antagonists & inhibitors Cyclin A - genetics Cyclin A2 Down-Regulation G1 arrest G1 Phase - drug effects Gene Expression Regulation, Neoplastic Humans Indolizines - pharmacology Phenanthrenes - pharmacology Phenanthroindolizidine Transcription, Genetic - drug effects Tylophora Tylophorine
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