Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma
The presence of calcification is the most significant ultrasonographic finding in evaluating thyroid nodules. Calcifications are more frequently detected in papillary thyroid carcinoma than in other thyroid lesions. However, the clinical significance of calcification, including clinical correlations...
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| Veröffentlicht in: | Modern pathology 2009-07, Vol.22 (7), p.887-894 |
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| description | The presence of calcification is the most significant ultrasonographic finding in evaluating thyroid nodules. Calcifications are more frequently detected in papillary thyroid carcinoma than in other thyroid lesions. However, the clinical significance of calcification, including clinical correlations and impact on survival, and the molecular mechanism responsible for calcification in papillary thyroid carcinoma remain uncertain. We performed a retrospective study of patients with primary common-type papillary thyroid carcinoma to determine the clinical correlations of calcification and its impact on survival. Histologically, calcification was classified as either psammoma bodies, stromal calcification, or bone formation. They were identified in 25, 47, and 13% of all 229 cases of papillary thyroid carcinoma, respectively. The presence of psammoma bodies was significantly correlated with gross lymph node metastasis and stage grouping. Both stromal calcification and bone formation were significantly correlated with patient age. In addition, stromal calcification was associated with pT classification and gross lymph node metastasis. Papillary thyroid carcinoma with, compared to that without, psammoma bodies was associated with poorer disease-free survival. We examined the quantitative expression of BMP-1, a metalloproteinase that is reported to be involved in bone and extracellular matrix formations, and found that its expression was significantly higher in tumors with psammoma bodies or with stromal calcification (
P
=0.0464 and 0.0272, respectively). These results suggest that the presence of psammoma bodies is a useful predictor of outcome for patients suffering from papillary thyroid carcinoma. |
| doi_str_mv | 10.1038/modpathol.2009.38 |
| format | Article |
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P
=0.0464 and 0.0272, respectively). These results suggest that the presence of psammoma bodies is a useful predictor of outcome for patients suffering from papillary thyroid carcinoma.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.2009.38</identifier><identifier>PMID: 19305382</identifier><identifier>CODEN: MODPEO</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adenocarcinoma, Papillary - metabolism ; Adenocarcinoma, Papillary - mortality ; Adenocarcinoma, Papillary - secondary ; Biomarkers, Tumor - metabolism ; Bone Morphogenetic Protein 1 - metabolism ; Calcification ; Calcinosis - diagnostic imaging ; Calcinosis - mortality ; Calcinosis - pathology ; Cancer therapies ; Clinical significance ; Disease-Free Survival ; Extracellular matrix ; Female ; Hospitals ; Humans ; Inclusion Bodies - diagnostic imaging ; Inclusion Bodies - metabolism ; Inclusion Bodies - pathology ; Japan - epidemiology ; Laboratory Medicine ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Lymphatic system ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Neoplasm Staging ; original-article ; Pathology ; Patients ; Retrospective Studies ; Stromal Cells - diagnostic imaging ; Stromal Cells - metabolism ; Stromal Cells - pathology ; Surgery ; Survival Rate ; Thyroid cancer ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - mortality ; Thyroid Neoplasms - pathology ; Ultrasonography</subject><ispartof>Modern pathology, 2009-07, Vol.22 (7), p.887-894</ispartof><rights>United States and Canadian Academy of Pathology, Inc. 2009</rights><rights>Copyright Nature Publishing Group Jul 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-86b9ed9ba611c4df90e838dd1fb4bceae91fbad6a9b870d073ef03ec15731a723</citedby><cites>FETCH-LOGICAL-c539t-86b9ed9ba611c4df90e838dd1fb4bceae91fbad6a9b870d073ef03ec15731a723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/221160359?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19305382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bai, Yanhua</creatorcontrib><creatorcontrib>Zhou, Gengyin</creatorcontrib><creatorcontrib>Nakamura, Misa</creatorcontrib><creatorcontrib>Ozaki, Takashi</creatorcontrib><creatorcontrib>Mori, Ichiro</creatorcontrib><creatorcontrib>Taniguchi, Emiko</creatorcontrib><creatorcontrib>Miyauchi, Akira</creatorcontrib><creatorcontrib>Ito, Yasuhiro</creatorcontrib><creatorcontrib>Kakudo, Kennichi</creatorcontrib><title>Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>The presence of calcification is the most significant ultrasonographic finding in evaluating thyroid nodules. Calcifications are more frequently detected in papillary thyroid carcinoma than in other thyroid lesions. However, the clinical significance of calcification, including clinical correlations and impact on survival, and the molecular mechanism responsible for calcification in papillary thyroid carcinoma remain uncertain. We performed a retrospective study of patients with primary common-type papillary thyroid carcinoma to determine the clinical correlations of calcification and its impact on survival. Histologically, calcification was classified as either psammoma bodies, stromal calcification, or bone formation. They were identified in 25, 47, and 13% of all 229 cases of papillary thyroid carcinoma, respectively. The presence of psammoma bodies was significantly correlated with gross lymph node metastasis and stage grouping. Both stromal calcification and bone formation were significantly correlated with patient age. In addition, stromal calcification was associated with pT classification and gross lymph node metastasis. Papillary thyroid carcinoma with, compared to that without, psammoma bodies was associated with poorer disease-free survival. We examined the quantitative expression of BMP-1, a metalloproteinase that is reported to be involved in bone and extracellular matrix formations, and found that its expression was significantly higher in tumors with psammoma bodies or with stromal calcification (
P
=0.0464 and 0.0272, respectively). These results suggest that the presence of psammoma bodies is a useful predictor of outcome for patients suffering from papillary thyroid carcinoma.</description><subject>Adenocarcinoma, Papillary - metabolism</subject><subject>Adenocarcinoma, Papillary - mortality</subject><subject>Adenocarcinoma, Papillary - secondary</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Bone Morphogenetic Protein 1 - metabolism</subject><subject>Calcification</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - mortality</subject><subject>Calcinosis - pathology</subject><subject>Cancer therapies</subject><subject>Clinical significance</subject><subject>Disease-Free Survival</subject><subject>Extracellular matrix</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inclusion Bodies - diagnostic imaging</subject><subject>Inclusion Bodies - metabolism</subject><subject>Inclusion Bodies - pathology</subject><subject>Japan - epidemiology</subject><subject>Laboratory Medicine</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>original-article</subject><subject>Pathology</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Stromal Cells - diagnostic imaging</subject><subject>Stromal Cells - metabolism</subject><subject>Stromal Cells - pathology</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - mortality</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Ultrasonography</subject><issn>0893-3952</issn><issn>1530-0285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkctu3CAYRlGVqpmmfYBsIhQpXcVT4PcFllHUmxSpi7ZrhAEnjAw4YEeatw-TGU2kLtqVMZzvcPkQOqdkTQnwzz6aSc0PcVwzQsQa-Bu0og2QijDenKAV4QIqEA07Re9z3hBC64azd-iUCiANcLZCm19LenJPasTOT0rPOA54ysr76BXuo9le4zyn8jNirUbtBqfV7GK4xiqYAgSLh5j8yxx2AU9qcuOo0hbPD9sUnSmxpF0ohg_o7aDGbD8evmfoz9cvv2-_V3c_v_24vbmrdANirnjbC2tEr1pKdW0GQSwHbgwd-rrXVllRRsq0SvS8I4Z0YAcCVtOmA6o6Bmfo0947pfi42DxL77K25VTBxiXLtquhaxvxX5ARAUDrtoCXf4GbuKRQLiEZo7Ql8GKje0inmHOyg5yS8-UlJCVyV5c81iV3dUngJXNxEC-9t-Y1ceinAGwP5LIU7m163flf1qt9KKh5SfZoPZI7sHDP6_Wzsg</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Bai, Yanhua</creator><creator>Zhou, Gengyin</creator><creator>Nakamura, Misa</creator><creator>Ozaki, Takashi</creator><creator>Mori, Ichiro</creator><creator>Taniguchi, Emiko</creator><creator>Miyauchi, Akira</creator><creator>Ito, Yasuhiro</creator><creator>Kakudo, Kennichi</creator><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma</title><author>Bai, Yanhua ; Zhou, Gengyin ; Nakamura, Misa ; Ozaki, Takashi ; Mori, Ichiro ; Taniguchi, Emiko ; Miyauchi, Akira ; Ito, Yasuhiro ; Kakudo, Kennichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-86b9ed9ba611c4df90e838dd1fb4bceae91fbad6a9b870d073ef03ec15731a723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenocarcinoma, Papillary - metabolism</topic><topic>Adenocarcinoma, Papillary - mortality</topic><topic>Adenocarcinoma, Papillary - secondary</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Bone Morphogenetic Protein 1 - metabolism</topic><topic>Calcification</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - mortality</topic><topic>Calcinosis - pathology</topic><topic>Cancer therapies</topic><topic>Clinical significance</topic><topic>Disease-Free Survival</topic><topic>Extracellular matrix</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inclusion Bodies - diagnostic imaging</topic><topic>Inclusion Bodies - metabolism</topic><topic>Inclusion Bodies - pathology</topic><topic>Japan - epidemiology</topic><topic>Laboratory Medicine</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>original-article</topic><topic>Pathology</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Stromal Cells - diagnostic imaging</topic><topic>Stromal Cells - metabolism</topic><topic>Stromal Cells - pathology</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - mortality</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Yanhua</creatorcontrib><creatorcontrib>Zhou, Gengyin</creatorcontrib><creatorcontrib>Nakamura, Misa</creatorcontrib><creatorcontrib>Ozaki, Takashi</creatorcontrib><creatorcontrib>Mori, Ichiro</creatorcontrib><creatorcontrib>Taniguchi, Emiko</creatorcontrib><creatorcontrib>Miyauchi, Akira</creatorcontrib><creatorcontrib>Ito, Yasuhiro</creatorcontrib><creatorcontrib>Kakudo, Kennichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Modern pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Yanhua</au><au>Zhou, Gengyin</au><au>Nakamura, Misa</au><au>Ozaki, Takashi</au><au>Mori, Ichiro</au><au>Taniguchi, Emiko</au><au>Miyauchi, Akira</au><au>Ito, Yasuhiro</au><au>Kakudo, Kennichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma</atitle><jtitle>Modern pathology</jtitle><stitle>Mod Pathol</stitle><addtitle>Mod Pathol</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>22</volume><issue>7</issue><spage>887</spage><epage>894</epage><pages>887-894</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><coden>MODPEO</coden><abstract>The presence of calcification is the most significant ultrasonographic finding in evaluating thyroid nodules. Calcifications are more frequently detected in papillary thyroid carcinoma than in other thyroid lesions. However, the clinical significance of calcification, including clinical correlations and impact on survival, and the molecular mechanism responsible for calcification in papillary thyroid carcinoma remain uncertain. We performed a retrospective study of patients with primary common-type papillary thyroid carcinoma to determine the clinical correlations of calcification and its impact on survival. Histologically, calcification was classified as either psammoma bodies, stromal calcification, or bone formation. They were identified in 25, 47, and 13% of all 229 cases of papillary thyroid carcinoma, respectively. The presence of psammoma bodies was significantly correlated with gross lymph node metastasis and stage grouping. Both stromal calcification and bone formation were significantly correlated with patient age. In addition, stromal calcification was associated with pT classification and gross lymph node metastasis. Papillary thyroid carcinoma with, compared to that without, psammoma bodies was associated with poorer disease-free survival. We examined the quantitative expression of BMP-1, a metalloproteinase that is reported to be involved in bone and extracellular matrix formations, and found that its expression was significantly higher in tumors with psammoma bodies or with stromal calcification (
P
=0.0464 and 0.0272, respectively). These results suggest that the presence of psammoma bodies is a useful predictor of outcome for patients suffering from papillary thyroid carcinoma.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>19305382</pmid><doi>10.1038/modpathol.2009.38</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma, Papillary - metabolism Adenocarcinoma, Papillary - mortality Adenocarcinoma, Papillary - secondary Biomarkers, Tumor - metabolism Bone Morphogenetic Protein 1 - metabolism Calcification Calcinosis - diagnostic imaging Calcinosis - mortality Calcinosis - pathology Cancer therapies Clinical significance Disease-Free Survival Extracellular matrix Female Hospitals Humans Inclusion Bodies - diagnostic imaging Inclusion Bodies - metabolism Inclusion Bodies - pathology Japan - epidemiology Laboratory Medicine Lymph Nodes - pathology Lymphatic Metastasis Lymphatic system Male Medical prognosis Medicine Medicine & Public Health Metastasis Middle Aged Neoplasm Staging original-article Pathology Patients Retrospective Studies Stromal Cells - diagnostic imaging Stromal Cells - metabolism Stromal Cells - pathology Surgery Survival Rate Thyroid cancer Thyroid Neoplasms - metabolism Thyroid Neoplasms - mortality Thyroid Neoplasms - pathology Ultrasonography |
| title | Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma |
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