Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal

Epidermal growth factor-like domain 7 (EGFL7) is a secreted factor implicated in cellular responses such as cell migration and blood vessel formation; however the molecular mechanisms underlying the effects of EGFL7 are largely unknown. Here we have identified transmembrane receptors of the Notch fa...

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Veröffentlicht in:	Nature cell biology 2009-07, Vol.11 (7), p.873-880
Hauptverfasser:	Babuke, Tanja, Dikic, Ivan, Nikolic, Iva, Schmidt, Mirko H.H, Plate, Karl H, Bicker, Frank, Picuric, Srdjan, Müller-Esterl, Werner, Meister, Jeannette
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Blood vessels Cancer Research Cell Biology Cell Differentiation - genetics Cell Differentiation - physiology Cell Line Cell Proliferation Cell receptors Cells, Cultured Cellular signal transduction Developmental Biology Endothelial Growth Factors - genetics Endothelial Growth Factors - metabolism Endothelial Growth Factors - physiology Epidermal growth factor Genetic aspects Humans letter Life Sciences Ligands Mice Neurons - cytology Neurons - metabolism Physiological aspects Protein Binding Receptors, Notch - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - genetics Signal Transduction - physiology Stem Cells Stem Cells - cytology Stem Cells - metabolism Two-Hybrid System Techniques
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