Epithelial neutrophil-activating peptide-78 recruits neutrophils into pleural effusion
The aim of this study was to investigate the presence of epithelial neutrophil-activating peptide (ENA)-78 in pleural effusions, as well as the chemoattractant activity of pleural ENA-78 on neutrophils. Pleural effusion and serum samples were collected from 75 patients who presented to the respirato...
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| Veröffentlicht in: | The European respiratory journal 2009-07, Vol.34 (1), p.184-190 |
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| creator | Liu, G-N Shi, H-Z Xie, Z-H Shen, H-H Huang, H-Q Deng, J-M Liang, Q-L Wu, Y-B |
| description | The aim of this study was to investigate the presence of epithelial neutrophil-activating peptide (ENA)-78 in pleural effusions, as well as the chemoattractant activity of pleural ENA-78 on neutrophils. Pleural effusion and serum samples were collected from 75 patients who presented to the respiratory institute (19 with malignant pleural effusion, 21 with tuberculous pleural effusion, 18 with infectious pleural effusion and 17 with transudative pleural effusion). The concentrations of ENA-78, myeloperoxidase and neutrophil elastase were determined, and the chemoattractant activity of ENA-78 for neutrophils both in vitro and in vivo was also observed. The concentrations of ENA-78, myeloperoxidase and neutrophil elastase in infectious pleural effusion were significantly higher than those in malignant, tuberculous and transudative groups, respectively (all p |
| doi_str_mv | 10.1183/09031936.00111908 |
| format | Article |
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Pleural effusion and serum samples were collected from 75 patients who presented to the respiratory institute (19 with malignant pleural effusion, 21 with tuberculous pleural effusion, 18 with infectious pleural effusion and 17 with transudative pleural effusion). The concentrations of ENA-78, myeloperoxidase and neutrophil elastase were determined, and the chemoattractant activity of ENA-78 for neutrophils both in vitro and in vivo was also observed. The concentrations of ENA-78, myeloperoxidase and neutrophil elastase in infectious pleural effusion were significantly higher than those in malignant, tuberculous and transudative groups, respectively (all p<0.01). Infectious pleural fluid was chemotactic for neutrophils in vitro and anti-ENA-78 antibody could partly inhibit these chemotactic effects. Intrapleural administration of ENA-78 produced a marked progressive influx of neutrophils into pleural space. Compared with noninfectious pleural effusion, ENA-78 appeared to be increased in infectious pleural effusion. Our data suggested that ENA-78 was able to induce neutrophil infiltration into pleural space and might be responsible for pleural neutrophil degranulation.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00111908</identifier><identifier>PMID: 19047312</identifier><language>eng</language><publisher>Leeds: Eur Respiratory Soc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Chemokine CXCL5 - metabolism ; Chemokine CXCL5 - physiology ; Chemotactic Factors - metabolism ; Female ; Humans ; Leukocyte Elastase - metabolism ; Male ; Medical sciences ; Middle Aged ; Models, Biological ; Neutrophils - immunology ; Neutrophils - metabolism ; Peroxidase - metabolism ; Pleural Effusion - immunology ; Pleural Effusion - metabolism ; Pneumology ; Prospective Studies ; Respiratory system : syndromes and miscellaneous diseases</subject><ispartof>The European respiratory journal, 2009-07, Vol.34 (1), p.184-190</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-f784320bc4993e109f82dae242f093e0faf09d3c06a41a0c19c0c30d574492993</citedby><cites>FETCH-LOGICAL-c402t-f784320bc4993e109f82dae242f093e0faf09d3c06a41a0c19c0c30d574492993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21614706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19047312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, G-N</creatorcontrib><creatorcontrib>Shi, H-Z</creatorcontrib><creatorcontrib>Xie, Z-H</creatorcontrib><creatorcontrib>Shen, H-H</creatorcontrib><creatorcontrib>Huang, H-Q</creatorcontrib><creatorcontrib>Deng, J-M</creatorcontrib><creatorcontrib>Liang, Q-L</creatorcontrib><creatorcontrib>Wu, Y-B</creatorcontrib><title>Epithelial neutrophil-activating peptide-78 recruits neutrophils into pleural effusion</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>The aim of this study was to investigate the presence of epithelial neutrophil-activating peptide (ENA)-78 in pleural effusions, as well as the chemoattractant activity of pleural ENA-78 on neutrophils. Pleural effusion and serum samples were collected from 75 patients who presented to the respiratory institute (19 with malignant pleural effusion, 21 with tuberculous pleural effusion, 18 with infectious pleural effusion and 17 with transudative pleural effusion). The concentrations of ENA-78, myeloperoxidase and neutrophil elastase were determined, and the chemoattractant activity of ENA-78 for neutrophils both in vitro and in vivo was also observed. The concentrations of ENA-78, myeloperoxidase and neutrophil elastase in infectious pleural effusion were significantly higher than those in malignant, tuberculous and transudative groups, respectively (all p<0.01). Infectious pleural fluid was chemotactic for neutrophils in vitro and anti-ENA-78 antibody could partly inhibit these chemotactic effects. Intrapleural administration of ENA-78 produced a marked progressive influx of neutrophils into pleural space. Compared with noninfectious pleural effusion, ENA-78 appeared to be increased in infectious pleural effusion. Our data suggested that ENA-78 was able to induce neutrophil infiltration into pleural space and might be responsible for pleural neutrophil degranulation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chemokine CXCL5 - metabolism</subject><subject>Chemokine CXCL5 - physiology</subject><subject>Chemotactic Factors - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocyte Elastase - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>Peroxidase - metabolism</subject><subject>Pleural Effusion - immunology</subject><subject>Pleural Effusion - metabolism</subject><subject>Pneumology</subject><subject>Prospective Studies</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0EtPxCAUBWBiNDo-foAb043uqvcWbMvSGF-JiRt1S5BeHAzTVqAa_71MnFFXN4HvnMVh7BDhFLHlZyCBo-T1KQAiSmg32Ay5lCUH4Jtstvwvl2CH7cb4llUtOG6znWxFw7Gaseer0aU5ead90dOUwjDOnS-1Se5DJ9e_FiONyXVUNm0RyITJpfhPxsL1aShGT1PIFWTtFN3Q77Mtq32kg9XdY0_XV4-Xt-X9w83d5cV9aQRUqbRNK3gFL0ZIyQlB2rbqNFWispAfwOp8O26g1gI1GJQGDIfuvBFCVjmzx05-escwvE8Uk1q4aMh73dMwRVU3gtd1AxniDzRhiDGQVWNwCx2-FIJajqnWY6r1mDlztCqfXhbU_SVW62VwvAI6Gu1t0L1x8ddVWKNooP5zc_c6_3SBVFxo73MtKgpvXChUmJf4Bq9giSk</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Liu, G-N</creator><creator>Shi, H-Z</creator><creator>Xie, Z-H</creator><creator>Shen, H-H</creator><creator>Huang, H-Q</creator><creator>Deng, J-M</creator><creator>Liang, Q-L</creator><creator>Wu, Y-B</creator><general>Eur Respiratory Soc</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Epithelial neutrophil-activating peptide-78 recruits neutrophils into pleural effusion</title><author>Liu, G-N ; Shi, H-Z ; Xie, Z-H ; Shen, H-H ; Huang, H-Q ; Deng, J-M ; Liang, Q-L ; Wu, Y-B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-f784320bc4993e109f82dae242f093e0faf09d3c06a41a0c19c0c30d574492993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chemokine CXCL5 - metabolism</topic><topic>Chemokine CXCL5 - physiology</topic><topic>Chemotactic Factors - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocyte Elastase - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - metabolism</topic><topic>Peroxidase - metabolism</topic><topic>Pleural Effusion - immunology</topic><topic>Pleural Effusion - metabolism</topic><topic>Pneumology</topic><topic>Prospective Studies</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, G-N</creatorcontrib><creatorcontrib>Shi, H-Z</creatorcontrib><creatorcontrib>Xie, Z-H</creatorcontrib><creatorcontrib>Shen, H-H</creatorcontrib><creatorcontrib>Huang, H-Q</creatorcontrib><creatorcontrib>Deng, J-M</creatorcontrib><creatorcontrib>Liang, Q-L</creatorcontrib><creatorcontrib>Wu, Y-B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, G-N</au><au>Shi, H-Z</au><au>Xie, Z-H</au><au>Shen, H-H</au><au>Huang, H-Q</au><au>Deng, J-M</au><au>Liang, Q-L</au><au>Wu, Y-B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epithelial neutrophil-activating peptide-78 recruits neutrophils into pleural effusion</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>34</volume><issue>1</issue><spage>184</spage><epage>190</epage><pages>184-190</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>The aim of this study was to investigate the presence of epithelial neutrophil-activating peptide (ENA)-78 in pleural effusions, as well as the chemoattractant activity of pleural ENA-78 on neutrophils. Pleural effusion and serum samples were collected from 75 patients who presented to the respiratory institute (19 with malignant pleural effusion, 21 with tuberculous pleural effusion, 18 with infectious pleural effusion and 17 with transudative pleural effusion). The concentrations of ENA-78, myeloperoxidase and neutrophil elastase were determined, and the chemoattractant activity of ENA-78 for neutrophils both in vitro and in vivo was also observed. The concentrations of ENA-78, myeloperoxidase and neutrophil elastase in infectious pleural effusion were significantly higher than those in malignant, tuberculous and transudative groups, respectively (all p<0.01). Infectious pleural fluid was chemotactic for neutrophils in vitro and anti-ENA-78 antibody could partly inhibit these chemotactic effects. Intrapleural administration of ENA-78 produced a marked progressive influx of neutrophils into pleural space. Compared with noninfectious pleural effusion, ENA-78 appeared to be increased in infectious pleural effusion. Our data suggested that ENA-78 was able to induce neutrophil infiltration into pleural space and might be responsible for pleural neutrophil degranulation.</abstract><cop>Leeds</cop><pub>Eur Respiratory Soc</pub><pmid>19047312</pmid><doi>10.1183/09031936.00111908</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Chemokine CXCL5 - metabolism Chemokine CXCL5 - physiology Chemotactic Factors - metabolism Female Humans Leukocyte Elastase - metabolism Male Medical sciences Middle Aged Models, Biological Neutrophils - immunology Neutrophils - metabolism Peroxidase - metabolism Pleural Effusion - immunology Pleural Effusion - metabolism Pneumology Prospective Studies Respiratory system : syndromes and miscellaneous diseases |
| title | Epithelial neutrophil-activating peptide-78 recruits neutrophils into pleural effusion |
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