Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord

Chondroitin sulfate proteoglycans are synthesized and deposited in the spinal cord following injury. These proteoglycans may restrict regeneration and plasticity and contribute to the limited recovery seen after an injury. Chondroitinase, a bacterial enzyme that catalyzes the hydrolysis of the chond...

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Veröffentlicht in:	Journal of neurotrauma 2005-02, Vol.22 (2), p.226-239
Hauptverfasser:	CAGGIANO, Anthony O, ZIMBER, Michael P, GANGULY, Anindita, BLIGHT, Andrew R, GRUSKIN, Elliott A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autonomic Agents - pharmacology Autonomic Agents - therapeutic use Biological and medical sciences Bladder Chondroitin ABC Lyase - pharmacology Chondroitin ABC Lyase - therapeutic use Contusions Enzymes Female Injuries of the nervous system and the skull. Diseases due to physical agents Locomotion - drug effects Locomotion - physiology Medical sciences Motor Activity - drug effects Nervous system Rats Rats, Long-Evans Recovery of Function - drug effects Recovery of Function - physiology Spinal cord injuries Spinal Cord Injuries - drug therapy Spinal Cord Injuries - physiopathology Thoracic Vertebrae Trauma Severity Indices Traumas. Diseases due to physical agents Urinary Bladder - drug effects Urinary Bladder - physiopathology
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