Crystal Structure of a Substrate Complex of Mycobacterium tuberculosis β-Ketoacyl-acyl Carrier Protein Synthase III (FabH) with Lauroyl-coenzyme A

β-Ketoacyl-acyl carrier protein synthase III (FabH) catalyzes a two step reaction that initiates the pathway of fatty acid biosynthesis in plants and bacteria. In Mycobacterium tuberculosis, FabH catalyzes extension of lauroyl, myristoyl and palmitoyl groups from which cell wall mycolic acids of the...

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Veröffentlicht in:	Journal of molecular biology 2005-03, Vol.346 (5), p.1313-1321
Hauptverfasser:	Musayev, Faik, Sachdeva, Sarbjot, Neel Scarsdale, J., Reynolds, K.A., Wright, H.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - chemistry 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - metabolism Acyl Coenzyme A - metabolism acyl-CoA Binding Sites Catalysis Crystallography, X-Ray Cysteine - chemistry Cysteine - genetics fatty acid biosynthesis ketoacyl-acyl carrier protein synthase III M. tuberculosis Models, Molecular Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycolic Acids - metabolism Protein Conformation substrate complex Substrate Specificity
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