Brain development needs sugar: the role of polysialic acid in controlling NCAM functions
Polysialic acid (polySia) is a major regulator of cell-cell interactions in the developing nervous system and a key factor in maintaining neural plasticity. As a polyanionic molecule with high water binding capacity, polySia increases the intercellular space and creates conditions that are permissiv...
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| Veröffentlicht in: | Biological chemistry 2009-07, Vol.390 (7), p.567-574 |
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| container_title | Biological chemistry |
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| creator | Mühlenhoff, Martina Oltmann-Norden, Imke Weinhold, Birgit Hildebrandt, Herbert Gerardy-Schahn, Rita |
| description | Polysialic acid (polySia) is a major regulator of cell-cell interactions in the developing nervous system and a key factor in maintaining neural plasticity. As a polyanionic molecule with high water binding capacity, polySia increases the intercellular space and creates conditions that are permissive for cellular plasticity. While the prevailing model highlights polySia as a non-specific regulator of cell-cell contacts, this review concentrates on recent studies in knockout mice indicating that a crucial function of polySia resides in controlling interactions mediated by its predominant protein carrier, the neural cell adhesion molecule NCAM. |
| doi_str_mv | 10.1515/BC.2009.078 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1431-6730 |
| ispartof | Biological chemistry, 2009-07, Vol.390 (7), p.567-574 |
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| language | eng |
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| source | MEDLINE; De Gruyter journals |
| subjects | Animals axon guidance Brain - growth & development Brain - metabolism Brain - pathology brain connectivity Cell Differentiation cell surface glycosylation cell-cell interaction Humans neural cell adhesion molecule NCAM Neural Cell Adhesion Molecules - metabolism polysialyltransferase Sialic Acids - biosynthesis Sialic Acids - metabolism Sialyltransferases - metabolism |
| title | Brain development needs sugar: the role of polysialic acid in controlling NCAM functions |
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