Benzodipyrazoles: a new class of potent CDK2 inhibitors

The synthesis and the preliminary structure–activity relationship results of this class are reported. The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion an...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-03, Vol.15 (5), p.1315-1319
Hauptverfasser:	D’Alessio, Roberto, Bargiotti, Alberto, Metz, Suzanne, Brasca, M. Gabriella, Cameron, Alexander, Ermoli, Antonella, Marsiglio, Aurelio, Polucci, Paolo, Roletto, Fulvia, Tibolla, Marcellino, Vazquez, Michael L., Vulpetti, Anna, Pevarello, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences CDC2-CDC28 Kinases - antagonists & inhibitors CDK2 Cell Line, Tumor Cell Proliferation - drug effects Crystallization Crystallography, X-Ray Cyclin A - antagonists & inhibitors Cyclin-Dependent Kinase 2 Cyclins Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - classification Enzyme Inhibitors - pharmacology General aspects Glycogen Synthase Kinase 3 - antagonists & inhibitors Humans Kinase selectivity Medical sciences Models, Molecular Molecular Structure Pharmacology. Drug treatments Pyrazoles - chemical synthesis Pyrazoles - classification Pyrazoles - pharmacology Structure-Activity Relationship Tumor cell proliferation inhibition
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