Decreased risk for atopic disorder associated with highly hyperreactive tuberculin skin test reaction in children and adolescents
Background It is speculated that the exposure to Mycobacterium tuberculosis, either by infection or by Bacillus Calmette‐Guérin vaccination, may inhibit the onset of atopy by the modification of immune profiles leading to a shift of TH1/TH2 balance to the TH1 side. Objective One hundred eighty‐six p...
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| Veröffentlicht in: | Pediatric pulmonology 2009-07, Vol.44 (7), p.701-705 |
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| container_title | Pediatric pulmonology |
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| creator | Marija, Maćešić Mirjana, Turkalj Žaneta, Jelčić Slavica, Dodig Branka, Kristić-Kirin Boro, Nogalo Davor, Plavec |
| description | Background
It is speculated that the exposure to Mycobacterium tuberculosis, either by infection or by Bacillus Calmette‐Guérin vaccination, may inhibit the onset of atopy by the modification of immune profiles leading to a shift of TH1/TH2 balance to the TH1 side.
Objective
One hundred eighty‐six patients hyperreactive at tuberculin skin test (TST) were examined in order to investigate the prevalence of atopic disorder, particularly referring to the association between the size of the TST induration and the prevalence of sensitization and manifest atopic disorder.
Methods
The study consisted of a family history record, patients' medical history assessment and clinical examination, skin prick test (SPT), serum total and allergen‐specific IgE (sIgE) measurement and eosinophil count.
Results
Atopic disorder was present in 49 (26.3%) patients tested. No significant difference between the groups based on the TST induration size (15–24 mm vs. ≥25 mm) was found for gender distribution, family atopy history, total IgE measurement, eosinophil count, positive SPT, and the presence of sIgE. A significant difference was found for the age median (14.0 years vs. 13.0 years), childhood atopy record, and manifest atopic disorder. No association between the size of the TST induration and the incidence of allergic sensitization was demonstrated. However, a significant inverse association between the size of the TST induration and manifest atopic disorder was demonstrated.
Conclusion
In patients highly hyperreactive at TST, the size of the induration is inversely associated with manifest atopic disorder. Pediatr Pulmonol. 2009; 44:701–705. © 2009 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ppul.21043 |
| format | Article |
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It is speculated that the exposure to Mycobacterium tuberculosis, either by infection or by Bacillus Calmette‐Guérin vaccination, may inhibit the onset of atopy by the modification of immune profiles leading to a shift of TH1/TH2 balance to the TH1 side.
Objective
One hundred eighty‐six patients hyperreactive at tuberculin skin test (TST) were examined in order to investigate the prevalence of atopic disorder, particularly referring to the association between the size of the TST induration and the prevalence of sensitization and manifest atopic disorder.
Methods
The study consisted of a family history record, patients' medical history assessment and clinical examination, skin prick test (SPT), serum total and allergen‐specific IgE (sIgE) measurement and eosinophil count.
Results
Atopic disorder was present in 49 (26.3%) patients tested. No significant difference between the groups based on the TST induration size (15–24 mm vs. ≥25 mm) was found for gender distribution, family atopy history, total IgE measurement, eosinophil count, positive SPT, and the presence of sIgE. A significant difference was found for the age median (14.0 years vs. 13.0 years), childhood atopy record, and manifest atopic disorder. No association between the size of the TST induration and the incidence of allergic sensitization was demonstrated. However, a significant inverse association between the size of the TST induration and manifest atopic disorder was demonstrated.
Conclusion
In patients highly hyperreactive at TST, the size of the induration is inversely associated with manifest atopic disorder. Pediatr Pulmonol. 2009; 44:701–705. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.21043</identifier><identifier>PMID: 19499572</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; allergic sensitization ; atopic disorder ; atopy ; Bacterial diseases ; Biological and medical sciences ; Child ; Child, Preschool ; Eosinophils ; Epidemiology. Vaccinations ; Female ; General aspects ; Human bacterial diseases ; Humans ; hygiene hypothesis ; hyperreactive tuberculin skin test ; Hypersensitivity ; Hypersensitivity, Delayed - blood ; Hypersensitivity, Delayed - immunology ; Immunoglobulin E - blood ; Infant ; Infectious diseases ; Leukocyte Count ; Male ; Medical sciences ; Pneumology ; Risk ; Skin Tests ; Tuberculosis and atypical mycobacterial infections ; Young Adult</subject><ispartof>Pediatric pulmonology, 2009-07, Vol.44 (7), p.701-705</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3953-c2898c0d0f6943bd48bd942238fdd3bb9701d091d89654ecbb0e3f12031399be3</citedby><cites>FETCH-LOGICAL-c3953-c2898c0d0f6943bd48bd942238fdd3bb9701d091d89654ecbb0e3f12031399be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.21043$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.21043$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21634597$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19499572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marija, Maćešić</creatorcontrib><creatorcontrib>Mirjana, Turkalj</creatorcontrib><creatorcontrib>Žaneta, Jelčić</creatorcontrib><creatorcontrib>Slavica, Dodig</creatorcontrib><creatorcontrib>Branka, Kristić-Kirin</creatorcontrib><creatorcontrib>Boro, Nogalo</creatorcontrib><creatorcontrib>Davor, Plavec</creatorcontrib><title>Decreased risk for atopic disorder associated with highly hyperreactive tuberculin skin test reaction in children and adolescents</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>Background
It is speculated that the exposure to Mycobacterium tuberculosis, either by infection or by Bacillus Calmette‐Guérin vaccination, may inhibit the onset of atopy by the modification of immune profiles leading to a shift of TH1/TH2 balance to the TH1 side.
Objective
One hundred eighty‐six patients hyperreactive at tuberculin skin test (TST) were examined in order to investigate the prevalence of atopic disorder, particularly referring to the association between the size of the TST induration and the prevalence of sensitization and manifest atopic disorder.
Methods
The study consisted of a family history record, patients' medical history assessment and clinical examination, skin prick test (SPT), serum total and allergen‐specific IgE (sIgE) measurement and eosinophil count.
Results
Atopic disorder was present in 49 (26.3%) patients tested. No significant difference between the groups based on the TST induration size (15–24 mm vs. ≥25 mm) was found for gender distribution, family atopy history, total IgE measurement, eosinophil count, positive SPT, and the presence of sIgE. A significant difference was found for the age median (14.0 years vs. 13.0 years), childhood atopy record, and manifest atopic disorder. No association between the size of the TST induration and the incidence of allergic sensitization was demonstrated. However, a significant inverse association between the size of the TST induration and manifest atopic disorder was demonstrated.
Conclusion
In patients highly hyperreactive at TST, the size of the induration is inversely associated with manifest atopic disorder. Pediatr Pulmonol. 2009; 44:701–705. © 2009 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>allergic sensitization</subject><subject>atopic disorder</subject><subject>atopy</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Eosinophils</subject><subject>Epidemiology. Vaccinations</subject><subject>Female</subject><subject>General aspects</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>hygiene hypothesis</subject><subject>hyperreactive tuberculin skin test</subject><subject>Hypersensitivity</subject><subject>Hypersensitivity, Delayed - blood</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immunoglobulin E - blood</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Risk</subject><subject>Skin Tests</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Young Adult</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0Eokvhwg9AvsABKcVf-fARWugiLVAJqj1ajj0hZr1JsB3KHvnnuGQpNy5jzczzzoxfhJ5SckYJYa-mafZnjBLB76EVJVIWRMjqPlo1dVkWVVPxE_Qoxm-E5J6kD9EJlULKsmYr9OsCTAAdweLg4g53Y8A6jZMz2Lo4Bgs5j3E0TqfM3LjU49597f0B94cJQtaa5H4ATnMLwczeDTjuckgQE16644BzwfTO2wAD1oPF2o4eooEhxcfoQad9hCfH9xRdv3v75XxdbD5dvj9_vSkMlyUvDGtkY4glXSUFb61oWisFY7zprOVtK2tCLZHUNrIqBZi2JcA7yginXMoW-Cl6scydwvh9ztepvcsXeK8HGOeoqlpwRnmTwZcLaMIYY4BOTcHtdTgoStSt4erWcPXH8Aw_O06d2z3Yf-jR4Qw8PwI6Gu27oAfj4h3HaMVFKevM0YW7cR4O_1mprq6uN3-XF4vGxQQ_7zQ67PJveF2q7cdLtf68vfjA3qzVlv8GIeKqnA</recordid><startdate>200907</startdate><enddate>200907</enddate><creator>Marija, Maćešić</creator><creator>Mirjana, Turkalj</creator><creator>Žaneta, Jelčić</creator><creator>Slavica, Dodig</creator><creator>Branka, Kristić-Kirin</creator><creator>Boro, Nogalo</creator><creator>Davor, Plavec</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200907</creationdate><title>Decreased risk for atopic disorder associated with highly hyperreactive tuberculin skin test reaction in children and adolescents</title><author>Marija, Maćešić ; Mirjana, Turkalj ; Žaneta, Jelčić ; Slavica, Dodig ; Branka, Kristić-Kirin ; Boro, Nogalo ; Davor, Plavec</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3953-c2898c0d0f6943bd48bd942238fdd3bb9701d091d89654ecbb0e3f12031399be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>allergic sensitization</topic><topic>atopic disorder</topic><topic>atopy</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Eosinophils</topic><topic>Epidemiology. Vaccinations</topic><topic>Female</topic><topic>General aspects</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>hygiene hypothesis</topic><topic>hyperreactive tuberculin skin test</topic><topic>Hypersensitivity</topic><topic>Hypersensitivity, Delayed - blood</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Immunoglobulin E - blood</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Risk</topic><topic>Skin Tests</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marija, Maćešić</creatorcontrib><creatorcontrib>Mirjana, Turkalj</creatorcontrib><creatorcontrib>Žaneta, Jelčić</creatorcontrib><creatorcontrib>Slavica, Dodig</creatorcontrib><creatorcontrib>Branka, Kristić-Kirin</creatorcontrib><creatorcontrib>Boro, Nogalo</creatorcontrib><creatorcontrib>Davor, Plavec</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marija, Maćešić</au><au>Mirjana, Turkalj</au><au>Žaneta, Jelčić</au><au>Slavica, Dodig</au><au>Branka, Kristić-Kirin</au><au>Boro, Nogalo</au><au>Davor, Plavec</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased risk for atopic disorder associated with highly hyperreactive tuberculin skin test reaction in children and adolescents</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2009-07</date><risdate>2009</risdate><volume>44</volume><issue>7</issue><spage>701</spage><epage>705</epage><pages>701-705</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>Background
It is speculated that the exposure to Mycobacterium tuberculosis, either by infection or by Bacillus Calmette‐Guérin vaccination, may inhibit the onset of atopy by the modification of immune profiles leading to a shift of TH1/TH2 balance to the TH1 side.
Objective
One hundred eighty‐six patients hyperreactive at tuberculin skin test (TST) were examined in order to investigate the prevalence of atopic disorder, particularly referring to the association between the size of the TST induration and the prevalence of sensitization and manifest atopic disorder.
Methods
The study consisted of a family history record, patients' medical history assessment and clinical examination, skin prick test (SPT), serum total and allergen‐specific IgE (sIgE) measurement and eosinophil count.
Results
Atopic disorder was present in 49 (26.3%) patients tested. No significant difference between the groups based on the TST induration size (15–24 mm vs. ≥25 mm) was found for gender distribution, family atopy history, total IgE measurement, eosinophil count, positive SPT, and the presence of sIgE. A significant difference was found for the age median (14.0 years vs. 13.0 years), childhood atopy record, and manifest atopic disorder. No association between the size of the TST induration and the incidence of allergic sensitization was demonstrated. However, a significant inverse association between the size of the TST induration and manifest atopic disorder was demonstrated.
Conclusion
In patients highly hyperreactive at TST, the size of the induration is inversely associated with manifest atopic disorder. Pediatr Pulmonol. 2009; 44:701–705. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19499572</pmid><doi>10.1002/ppul.21043</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent allergic sensitization atopic disorder atopy Bacterial diseases Biological and medical sciences Child Child, Preschool Eosinophils Epidemiology. Vaccinations Female General aspects Human bacterial diseases Humans hygiene hypothesis hyperreactive tuberculin skin test Hypersensitivity Hypersensitivity, Delayed - blood Hypersensitivity, Delayed - immunology Immunoglobulin E - blood Infant Infectious diseases Leukocyte Count Male Medical sciences Pneumology Risk Skin Tests Tuberculosis and atypical mycobacterial infections Young Adult |
| title | Decreased risk for atopic disorder associated with highly hyperreactive tuberculin skin test reaction in children and adolescents |
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