Celiac disease and intestinal metaplasia of the esophagus (barrett's esophagus)
Previous studies on celiac patients demonstrated that exposure to gliadin alters the motility of the upper gastrointestinal tract, leading to increased acid reflux. No literature is available regarding the possible presence of specialized intestinal metaplasia of the esophagus as a consequence of ch...
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| Veröffentlicht in: | Digestive diseases and sciences 2005, Vol.50 (1), p.126-129 |
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| creator | MAIERON, Roberto ELLI, Luca MARINO, Marco FLORIANI, Irene MINERVA, Francesco AVELLINI, Claudio FALCONIERI, Giovanni PIZZOLITTO, Stefano ZILLI, Maurizio |
| description | Previous studies on celiac patients demonstrated that exposure to gliadin alters the motility of the upper gastrointestinal tract, leading to increased acid reflux. No literature is available regarding the possible presence of specialized intestinal metaplasia of the esophagus as a consequence of chronic reflux in adult celiac patients. Our purpose was to evaluate endoscopically and histologically the esophagi of a group of untreated celiac patients. We studied 60 celiac patients, 13 men and 47 women (mean age, 40 +/- 14 [SD] years; range, 18-80 years), at their first endoscopy (following a normal diet). The distal esophagus was evaluated and multiple biopsies were taken. Hematoxylin-eosin and alcian blue stainings were performed. A group of nonceliac, age- and sex-matched patients was used as a control. We found intestinal metaplasia in the distal esophagus of 16 of 60 (26.6%) celiacs (mean age, 45 +/- 13 years; range, 27-75 years), in comparison with a control-group prevalence of 10.9% (OR, 3.9; 95% CI, 1.4-11.2%). Among the celiac group with metaplasia, only one patient had reflux-like symptoms. None had esophagitis. In conclusion, we observed an increased prevalence of esophageal metaplasia in patients with celiac disease. This finding could be the result of motor abnormalities leading to chronic acid reflux, combined with a mucosa which is sensitive to gliadin. |
| doi_str_mv | 10.1007/s10620-005-1289-6 |
| format | Article |
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No literature is available regarding the possible presence of specialized intestinal metaplasia of the esophagus as a consequence of chronic reflux in adult celiac patients. Our purpose was to evaluate endoscopically and histologically the esophagi of a group of untreated celiac patients. We studied 60 celiac patients, 13 men and 47 women (mean age, 40 +/- 14 [SD] years; range, 18-80 years), at their first endoscopy (following a normal diet). The distal esophagus was evaluated and multiple biopsies were taken. Hematoxylin-eosin and alcian blue stainings were performed. A group of nonceliac, age- and sex-matched patients was used as a control. We found intestinal metaplasia in the distal esophagus of 16 of 60 (26.6%) celiacs (mean age, 45 +/- 13 years; range, 27-75 years), in comparison with a control-group prevalence of 10.9% (OR, 3.9; 95% CI, 1.4-11.2%). Among the celiac group with metaplasia, only one patient had reflux-like symptoms. None had esophagitis. In conclusion, we observed an increased prevalence of esophageal metaplasia in patients with celiac disease. This finding could be the result of motor abnormalities leading to chronic acid reflux, combined with a mucosa which is sensitive to gliadin.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-005-1289-6</identifier><identifier>PMID: 15712649</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Barrett Esophagus - complications ; Barrett Esophagus - epidemiology ; Barrett Esophagus - pathology ; Biological and medical sciences ; Celiac Disease - complications ; Celiac Disease - pathology ; Esophagoscopy ; Esophagus ; Esophagus - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Prevalence ; Stomach. 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Anus</subject><ispartof>Digestive diseases and sciences, 2005, Vol.50 (1), p.126-129</ispartof><rights>2005 INIST-CNRS</rights><rights>Springer Science + Business Media, Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-51eadc2669843a3c76ec23df1231bc3fd8cb39d2f429aaf067bc0f25e9d372dd3</citedby><cites>FETCH-LOGICAL-c356t-51eadc2669843a3c76ec23df1231bc3fd8cb39d2f429aaf067bc0f25e9d372dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16684128$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15712649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAIERON, Roberto</creatorcontrib><creatorcontrib>ELLI, Luca</creatorcontrib><creatorcontrib>MARINO, Marco</creatorcontrib><creatorcontrib>FLORIANI, Irene</creatorcontrib><creatorcontrib>MINERVA, Francesco</creatorcontrib><creatorcontrib>AVELLINI, Claudio</creatorcontrib><creatorcontrib>FALCONIERI, Giovanni</creatorcontrib><creatorcontrib>PIZZOLITTO, Stefano</creatorcontrib><creatorcontrib>ZILLI, Maurizio</creatorcontrib><title>Celiac disease and intestinal metaplasia of the esophagus (barrett's esophagus)</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Previous studies on celiac patients demonstrated that exposure to gliadin alters the motility of the upper gastrointestinal tract, leading to increased acid reflux. No literature is available regarding the possible presence of specialized intestinal metaplasia of the esophagus as a consequence of chronic reflux in adult celiac patients. Our purpose was to evaluate endoscopically and histologically the esophagi of a group of untreated celiac patients. We studied 60 celiac patients, 13 men and 47 women (mean age, 40 +/- 14 [SD] years; range, 18-80 years), at their first endoscopy (following a normal diet). The distal esophagus was evaluated and multiple biopsies were taken. Hematoxylin-eosin and alcian blue stainings were performed. A group of nonceliac, age- and sex-matched patients was used as a control. We found intestinal metaplasia in the distal esophagus of 16 of 60 (26.6%) celiacs (mean age, 45 +/- 13 years; range, 27-75 years), in comparison with a control-group prevalence of 10.9% (OR, 3.9; 95% CI, 1.4-11.2%). Among the celiac group with metaplasia, only one patient had reflux-like symptoms. None had esophagitis. In conclusion, we observed an increased prevalence of esophageal metaplasia in patients with celiac disease. This finding could be the result of motor abnormalities leading to chronic acid reflux, combined with a mucosa which is sensitive to gliadin.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Barrett Esophagus - complications</subject><subject>Barrett Esophagus - epidemiology</subject><subject>Barrett Esophagus - pathology</subject><subject>Biological and medical sciences</subject><subject>Celiac Disease - complications</subject><subject>Celiac Disease - pathology</subject><subject>Esophagoscopy</subject><subject>Esophagus</subject><subject>Esophagus - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Prevalence</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Prevalence</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. 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No literature is available regarding the possible presence of specialized intestinal metaplasia of the esophagus as a consequence of chronic reflux in adult celiac patients. Our purpose was to evaluate endoscopically and histologically the esophagi of a group of untreated celiac patients. We studied 60 celiac patients, 13 men and 47 women (mean age, 40 +/- 14 [SD] years; range, 18-80 years), at their first endoscopy (following a normal diet). The distal esophagus was evaluated and multiple biopsies were taken. Hematoxylin-eosin and alcian blue stainings were performed. A group of nonceliac, age- and sex-matched patients was used as a control. We found intestinal metaplasia in the distal esophagus of 16 of 60 (26.6%) celiacs (mean age, 45 +/- 13 years; range, 27-75 years), in comparison with a control-group prevalence of 10.9% (OR, 3.9; 95% CI, 1.4-11.2%). Among the celiac group with metaplasia, only one patient had reflux-like symptoms. None had esophagitis. In conclusion, we observed an increased prevalence of esophageal metaplasia in patients with celiac disease. This finding could be the result of motor abnormalities leading to chronic acid reflux, combined with a mucosa which is sensitive to gliadin.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>15712649</pmid><doi>10.1007/s10620-005-1289-6</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Barrett Esophagus - complications Barrett Esophagus - epidemiology Barrett Esophagus - pathology Biological and medical sciences Celiac Disease - complications Celiac Disease - pathology Esophagoscopy Esophagus Esophagus - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Other diseases. Semiology Prevalence Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Celiac disease and intestinal metaplasia of the esophagus (barrett's esophagus) |
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