Flow perfusion enhances the calcified matrix deposition of marrow stromal cells in biodegradable nonwoven fiber mesh scaffolds

In this study, we report on the ability of resorbable poly(L-lactic acid) (PLLA) nonwoven scaffolds to support the attachment, growth, and differentiation of marrow stromal cells (MSCs) under fluid flow. Rat MSCs were isolated from young male Wistar rats and expanded using established methods. The c...

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Veröffentlicht in:	Annals of biomedical engineering 2005-01, Vol.33 (1), p.63-70
Hauptverfasser:	Sikavitsas, Vassilios I, Bancroft, Gregory N, Lemoine, Jeremy J, Liebschner, Michael A K, Dauner, Martin, Mikos, Antonios G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials Biodegradation Bioreactors Bone Marrow Cells - cytology Bone Marrow Cells - physiology Calcification, Physiologic Cell Differentiation - physiology Cell Proliferation Cells, Cultured Extracellular Matrix - physiology Fluid flow Lactic Acid Male Perfusion Polyesters Polymers Porosity Rats Rats, Wistar Stromal Cells - physiology Tissue Engineering - methods
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