The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism

Arc1p, a yeast tRNA-binding protein, forms a complex with the aminoacyl-tRNA synthetases, methionyl tRNA synthetase (MetRS) and glutamyl tRNA synthetase (GluRS). Although this complex localizes normally in the cytoplasm, in the absence of Arc1p the two free synthetases are also found inside the nucl...

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Veröffentlicht in:	FEBS letters 2005-02, Vol.579 (5), p.969-975
Hauptverfasser:	Galani, Kyriaki, Hurt, Ed, Simos, George
Format:	Artikel
Sprache:	eng
Schlagworte:	ARC1 Cell Nucleus - metabolism Cytoplasm - metabolism Exportin 1 Protein GFP GluRS Glutamate-tRNA Ligase - metabolism glutamyl tRNA synthetase green fluorescent protein Karyopherins - metabolism leptomycin B LMB Methionine-tRNA Ligase - metabolism methionyl tRNA synthetase MetRS Mutation - genetics NLS nuclear localization signal Nuclear Proteins - metabolism open reading frame ORF Protein Sorting Signals - physiology Protein Transport Receptors, Cytoplasmic and Nuclear - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Transfer RNA Aminoacylation TRBD tRNA tRNA binding domain XPO1
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