Measurement of serotonin in platelet depleted plasma by liquid chromatography tandem mass spectrometry

5-Hydroxytryptamine (5-HT) in human platelet depleted plasma (PDP) is a biomarker in functional gastrointestinal disorders (FGID), with levels reflecting acute changes in circulating 5-HT concentration. PDP 5-HT is currently measured by reversed phase high performance liquid chromatography (HPLC) fl...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2009-07, Vol.877 (22), p.2163-2167
Hauptverfasser:	Monaghan, Phillip J., Brown, Heather A., Houghton, Lesley A., Keevil, Brian G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Blood Platelets - metabolism Chromatography, Liquid - methods Functional gastrointestinal disorders Fundamental and applied biological sciences. Psychology Gastrointestinal Diseases - diagnosis Gastrointestinal Diseases - metabolism General pharmacology Humans LC–MS/MS Medical sciences Pharmacology. Drug treatments Protein precipitation Serotonin Serotonin - blood Serotonin - chemistry Serotonin - metabolism Tandem Mass Spectrometry - methods
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