Cooperative interaction of C/EBPβ and Tat modulates MCP-1 gene transcription in astrocytes

The chemoattractant protein 1 (MCP-1) is one of the most potent monocyte chemoattractants whose level is elevated during the course of AIDS dementia. Earlier studies showed that HIV-1 Tat protein is able to induce transcription of the MCP-1 promoter in astrocytic cells. Furthermore, the TGFβ-1 signa...

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Veröffentlicht in:	Journal of neuroimmunology 2005-03, Vol.160 (1), p.219-227
Hauptverfasser:	Abraham, Selvajothi, Sweet, Thersa, Sawaya, Bassel E., Rappaport, Jay, Khalili, Kamel, Amini, Shohreh
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - genetics Amino Acid Motifs - genetics Astrocytes Astrocytes - immunology Astrocytes - metabolism Astrocytes - virology C/EBPβ CCAAT-Enhancer-Binding Protein-beta - metabolism CCAAT-Enhancer-Binding Protein-beta - physiology CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - metabolism Chemokine Chemokine CCL2 - genetics Chemokine CCL2 - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Gene Products, tat - metabolism Gene Products, tat - physiology Glutathione Transferase - genetics HIV-1 HIV-1 - immunology Human immunodeficiency virus 1 Humans Promoter Regions, Genetic Protein Structure, Tertiary - genetics Recombinant Fusion Proteins - genetics Sequence Deletion Signal Transduction - genetics Signal Transduction - immunology Smad3 Protein tat Gene Products, Human Immunodeficiency Virus Trans-Activators - genetics Trans-Activators - physiology Transcription Transcription Factor CHOP Transcription Factors - genetics Transcription Factors - metabolism Transfection Transforming Growth Factor beta - physiology
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