Dual Phospholipase C/Diacylglycerol Requirement for Protein Kinase D1 Activation in Lymphocytes

The serine/threonine kinase protein kinase D1 (PKD1) is a protein kinase C (PKC) substrate that mediates antigen receptor signal transduction in lymphocytes. PKC phosphorylates serines 744/748 within the PKD1 catalytic domain, and this is proposed to be necessary and sufficient for enzyme activation...

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Veröffentlicht in:	The Journal of biological chemistry 2005-02, Vol.280 (7), p.6245-6251
Hauptverfasser:	Wood, C. David, Marklund, Ulrica, Cantrell, Doreen A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Cell Line, Tumor Chickens Diglycerides - metabolism Enzyme Activation Humans Lymphocytes - enzymology Lymphocytes - metabolism Mice Mutation - genetics Phospholipase C gamma Phosphorylation Protein Kinase C - antagonists & inhibitors Protein Kinase C - chemistry Protein Kinase C - genetics Protein Kinase C - metabolism Protein Structure, Tertiary Serine - metabolism Type C Phospholipases - deficiency Type C Phospholipases - genetics Type C Phospholipases - metabolism
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