Synthesis and Biological Evaluation of Asiatic Acid Derivatives as Inhibitors of Glycogen Phosphorylases

Twenty‐four asiatic acid derivatives have been synthesized and biologically evaluated as inhibitors of glycogen phosphorylase (GP). Within this series of compounds, asiatic acid benzyl ester (23; IC50=3.8 μM) exhibited more potent activity than its parent compound 1 (IC50=17 μM). SAR Analysis showed...

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Veröffentlicht in:	Chemistry & biodiversity 2009-06, Vol.6 (6), p.864-874
Hauptverfasser:	Zhang, Liying, Chen, Jun, Gong, Yanchun, Liu, Jun, Zhang, Luyong, Hua, Weiyi, Sun, Hongbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidiabetic activity Asiatic acid derivatives Centella asiatica Diabetes Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glycogen phosphorylase Glycogen Phosphorylase - antagonists & inhibitors Glycogen Phosphorylase - metabolism Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Inhibitors Pentacyclic Triterpenes Rabbits Structure > activity relationships (SAR) Structure-Activity Relationship Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - pharmacology Ursanes
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